ENSGALG00000036327


Gallus gallus

Features
Gene ID: ENSGALG00000036327
  
Biological name :NGEF
  
Synonyms : neuronal guanine nucleotide exchange factor / NGEF
  
Possible biological names infered from orthology : Ephexin-1 / Q8CHT1 / Q8N5V2
  
Species: Gallus gallus
  
Chr. number: 9
Strand: -1
Band:
Gene start: 1052566
Gene end: 1088975
  
Corresponding Affymetrix probe sets: GgaAffx.20383.1.S1_s_at (Chicken Array)   GgaAffx.981.2.A1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052175
Ensembl peptide - ENSGALP00000052744
Ensembl peptide - ENSGALP00000045148
NCBI entrez gene - 424744     See in Manteia.
RefSeq - XM_015276864
RefSeq - XM_015276860
RefSeq - XM_015276861
RefSeq - XM_015276862
RefSeq - XM_015276863
RefSeq - NM_001010841
RefSeq - XM_015276858
RefSeq - XM_015276859
RefSeq Peptide - NP_001010841
swissprot - A0A1D5PIV8
swissprot - A0A1D5NXP9
swissprot - Q5ZK41
Ensembl - ENSGALG00000036327
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ngefENSDARG00000076179Danio rerio
 NGEFENSG00000066248Homo sapiens
 NgefENSMUSG00000026259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
E9Q7D5* / Q12774* / ARHGEF5* / Rho guanine nucleotide exchange factor 5*ENSGALG0000001727636
ARHGEF16 / Rho guanine nucleotide exchange factor 16 / Q3U5C8* / Q5VV41*ENSGALG0000000105833
ARHGEF26 / Rho guanine nucleotide exchange factor 26 / Q96DR7* / Rho guanine nucleotide exchange factor (GEF) 26*ENSGALG0000001035230


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / complex
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex






 

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