ENSGALG00000000280


Gallus gallus

Features
Gene ID: ENSGALG00000000280
  
Biological name :EFNA5
  
Synonyms : EFNA5 / ephrin-A5 precursor
  
Possible biological names infered from orthology : ephrin A5 / O08543 / P52803
  
Species: Gallus gallus
  
Chr. number: Z
Strand: 1
Band:
Gene start: 48046148
Gene end: 48249653
  
Corresponding Affymetrix probe sets: Gga.651.1.S1_at (Chicken Array)   Gga.651.1.S2_at (Chicken Array)   Gga.651.1.S2_s_at (Chicken Array)   GgaAffx.20430.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000045820
Ensembl peptide - ENSGALP00000058467
Ensembl peptide - ENSGALP00000053687
Ensembl peptide - ENSGALP00000052616
NCBI entrez gene - 396100     See in Manteia.
RefSeq - XM_015280413
RefSeq - NM_205184
RefSeq - XM_015280412
RefSeq Peptide - NP_990515
swissprot - A0A1D5NZK2
swissprot - A0A1D5PZQ2
swissprot - A0A1D5PLH1
swissprot - A0A1D5PII3
Ensembl - ENSGALG00000000280
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna5aENSDARG00000089790Danio rerio
 EFNA5ENSG00000184349Homo sapiens
 Efna5ENSMUSG00000048915Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNA2 / ephrin-A2 precursor / O43921* / P52801* / ephrin A2*ENSGALG0000003862948


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IEA
 biological_processGO:0022604 regulation of cell morphogenesis IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048668 collateral sprouting IEA
 biological_processGO:0048672 positive regulation of collateral sprouting IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IEA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IEA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005169 neurotrophin TRKB receptor binding IEA
 molecular_functionGO:0045499 chemorepellent activity IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004741 EPHB2 / EPH receptor B2 / P29323* / P54763* / Ephrin type-B receptor 2 *  / reaction
 ENSGALG00000006609 EPHB1 / EPH receptor B1 / P54762* / Q8CBF3* / Ephrin type-B receptor 1 *  / reaction
 ENSGALG00000015842 TIAM1 / T cell lymphoma invasion and metastasis 1 / Q13009*  / complex / reaction
 ENSGALG00000000280 EFNA5 / ephrin-A5 precursor / O08543* / P52803* / ephrin A5*  / - / complex / reaction
 ENSGALG00000039327 VAV3 / vav guanine nucleotide exchange factor 3 / Q9R0C8* / Q9UKW4* / vav 3 oncogene*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction
 ENSGALG00000014860 YES1 / P09324 / Tyrosine-protein kinase Yes / Q04736* / P07947* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSGALG00000042321 LYN / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSGALG00000015022 FYN / tyrosine-protein kinase Fyn / P06241* / P39688* / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSGALG00000029175 EFNB2 / ephrin B2 / P52799* / P52800*  / reaction
 ENSGALG00000036327 NGEF / neuronal guanine nucleotide exchange factor / Q8CHT1* / Q8N5V2* / Ephexin-1 *  / complex






 

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