ENSMUSG00000048915


Mus musculus

Features
Gene ID: ENSMUSG00000048915
  
Biological name :Efna5
  
Synonyms : Efna5 / Ephrin-A5 / O08543
  
Possible biological names infered from orthology : P52803
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.1
Gene start: 62604184
Gene end: 62881317
  
Corresponding Affymetrix probe sets: 10452419 (MoGene1.0st)   1421796_a_at (Mouse Genome 430 2.0 Array)   1436866_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076115
Ensembl peptide - ENSMUSP00000077883
NCBI entrez gene - 13640     See in Manteia.
MGI - MGI:107444
RefSeq - XM_006523598
RefSeq - NM_010109
RefSeq - NM_207654
RefSeq Peptide - NP_997537
RefSeq Peptide - NP_034239
swissprot - O08543
Ensembl - ENSMUSG00000048915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna5aENSDARG00000089790Danio rerio
 EFNA5ENSGALG00000000280Gallus gallus
 EFNA5ENSG00000184349Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efna2 / P52801 / Ephrin-A2 / O43921*ENSMUSG0000000307045
Efna3 / O08545 / Ephrin-A3 / P52797*ENSMUSG0000002803936
Efna1 / P52793 / Ephrin-A1 Ephrin-A1, secreted form / P20827* / ephrin A1*ENSMUSG0000002795436
Efna4 / O08542 / Ephrin-A4 / P52798*ENSMUSG0000002804032


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0022407 regulation of cell-cell adhesion IDA
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IDA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0043087 regulation of GTPase activity ISS
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 biological_processGO:0048668 collateral sprouting IDA
 biological_processGO:0048672 positive regulation of collateral sprouting IMP
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051893 regulation of focal adhesion assembly ISO
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISO
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IDA
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading ISO
 biological_processGO:1904322 cellular response to forskolin IDA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005912 adherens junction IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane ISS
 cellular_componentGO:0046658 anchored component of plasma membrane IBA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005169 neurotrophin TRKB receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045499 chemorepellent activity IDA
 molecular_functionGO:0046875 ephrin receptor binding IPI


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Efna2tm1Jgf/Efna2tm1Jgf,Efna5tm1Ddmo/Efna5tm1Ddmo
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Efna2tm1Jgf/Efna2+,Efna5tm1Ddmo/Efna5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001319 irregularly shaped pupil "shape defects in the aperture of the iris through which light rays enter the eye, usually circular " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0001890 anencephaly "absence of the bones of the cranial vault and absent or rudimentary cerebral and cerebellar hemispheres, brainstem, and basal ganglia" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:31571]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rxratm2Ipc/Rxratm4Ipc,Tg(KRT14-cre)1Ipc/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0008528 polycystic kidney "the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0009945 abnormal accessory olfactory bulb morphology "any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tln2tm1Crit/Tln2tm1Crit
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0011259 abnormal cephalic neural fold morphology "any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo" [ISBN:0-683-40008-8, MGI:csmith]
Show

Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr