ENSMUSG00000003070


Mus musculus

Features
Gene ID: ENSMUSG00000003070
  
Biological name :Efna2
  
Synonyms : Efna2 / Ephrin-A2 / P52801
  
Possible biological names infered from orthology : O43921
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80179482
Gene end: 80190010
  
Corresponding Affymetrix probe sets: 10364722 (MoGene1.0st)   1417521_at (Mouse Genome 430 2.0 Array)   1444606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003154
NCBI entrez gene - 13637     See in Manteia.
MGI - MGI:102707
RefSeq - NM_007909
RefSeq Peptide - NP_031935
swissprot - P52801
Ensembl - ENSMUSG00000003070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna2aENSDARG00000031372Danio rerio
 efna2bENSDARG00000079740Danio rerio
 EFNA2ENSGALG00000038629Gallus gallus
 EFNA2ENSG00000099617Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efna5 / O08543 / Ephrin-A5 / P52803*ENSMUSG0000004891549
Efna3 / O08545 / Ephrin-A3 / P52797*ENSMUSG0000002803943
Efna1 / P52793 / Ephrin-A1 Ephrin-A1, secreted form / P20827* / ephrin A1*ENSMUSG0000002795439
Efna4 / O08542 / Ephrin-A4 / P52798*ENSMUSG0000002804036


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0021772 olfactory bulb development IEA
 biological_processGO:0030316 osteoclast differentiation IDA
 biological_processGO:0046849 bone remodeling IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031594 neuromuscular junction IEA
 cellular_componentGO:0043204 perikaryon IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Pgrtm1.2Mlia/Pgrtm1.2Mlia
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Efna2tm1Jgf/Efna2tm1Jgf,Efna5tm1Ddmo/Efna5tm1Ddmo
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Efna2tm1Jgf/Efna2+,Efna5tm1Ddmo/Efna5+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002634 abnormal sensorimotor gating "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfe2l1tm1Jefc/Nfe2l1tm1Ywk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000054693 Adam10 / O35598 / Disintegrin and metalloproteinase domain-containing protein 10 / O14672* / ADAM metallopeptidase domain 10*  / complex






 

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