ENSMUSG00000028039


Mus musculus

Features
Gene ID: ENSMUSG00000028039
  
Biological name :Efna3
  
Synonyms : Efna3 / Ephrin-A3 / O08545
  
Possible biological names infered from orthology : P52797
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89313899
Gene end: 89322965
  
Corresponding Affymetrix probe sets: 10499545 (MoGene1.0st)   1431170_at (Mouse Genome 430 2.0 Array)   1455344_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029673
Ensembl peptide - ENSMUSP00000143539
NCBI entrez gene - 13638     See in Manteia.
MGI - MGI:106644
RefSeq - XM_017319452
RefSeq - NM_010108
RefSeq - XM_006500988
RefSeq Peptide - NP_034238
swissprot - O08545
swissprot - A0A0G2JGE9
Ensembl - ENSMUSG00000028039
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna3aENSDARG00000014675Danio rerio
 efna3bENSDARG00000098295Danio rerio
 EFNA3ENSG00000143590Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efna2 / P52801 / Ephrin-A2 / O43921*ENSMUSG0000000307039
Efna4 / O08542 / Ephrin-A4 / P52798*ENSMUSG0000002804038
Efna5 / O08543 / Ephrin-A5 / P52803*ENSMUSG0000004891536
Efna1 / P52793 / Ephrin-A1 Ephrin-A1, secreted form / P20827* / ephrin A1*ENSMUSG0000002795435


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0045664 regulation of neuron differentiation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001382 abnormal nursing "females do not nurse pups or nurse pups infrequently" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001413 abnormal response to new environment "altered investigative behavior from controls in reactions associated with placing an animal in a new location" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001441 increased grooming behavior "increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0002634 abnormal sensorimotor gating "malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)" [J:42758, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0002912 abnormal excitatory postsynaptic potential "defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Sox2tm4.1Skn/Sox2tm4.1Skn,Tg(Sox2-cre/ERT2)1Skn/0
Genetic Background: involves: 129S1/Sv * 129S4/SvJae

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il1r1tm1Quan/Il1r1tm1Quan,Lyz2tm1(cre)Ifo/Lyz2tm1(cre)Ifo
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.1Mcba/Trp53tm1.1Mcba
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Large1myd/Large1myd
Genetic Background: B6.Cg-Large1myd/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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