ENSMUSG00000027954


Mus musculus

Features
Gene ID: ENSMUSG00000027954
  
Biological name :Efna1
  
Synonyms : Efna1 / Ephrin-A1 Ephrin-A1, secreted form / P52793
  
Possible biological names infered from orthology : ephrin A1 / P20827
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89271733
Gene end: 89281142
  
Corresponding Affymetrix probe sets: 10499536 (MoGene1.0st)   1416895_at (Mouse Genome 430 2.0 Array)   1448510_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112904
Ensembl peptide - ENSMUSP00000113098
Ensembl peptide - ENSMUSP00000029566
NCBI entrez gene - 13636     See in Manteia.
MGI - MGI:103236
RefSeq - NM_010107
RefSeq - NM_001162425
RefSeq Peptide - NP_001155897
RefSeq Peptide - NP_034237
swissprot - P52793
swissprot - D3Z7A6
swissprot - D3YTT5
Ensembl - ENSMUSG00000027954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna1aENSDARG00000030326Danio rerio
 efna1bENSDARG00000018787Danio rerio
 EFNA1ENSG00000169242Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Efna2 / P52801 / Ephrin-A2 / O43921*ENSMUSG0000000307040
Efna5 / O08543 / Ephrin-A5 / P52803*ENSMUSG0000004891540
Efna3 / O08545 / Ephrin-A3 / P52797*ENSMUSG0000002803939
Efna4 / O08542 / Ephrin-A4 / P52798*ENSMUSG0000002804034


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003180 aortic valve morphogenesis IMP
 biological_processGO:0003183 mitral valve morphogenesis IMP
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation IMP
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0014028 notochord formation IGI
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0030182 neuron differentiation IDA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IEA
 biological_processGO:0043409 negative regulation of MAPK cascade IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IDA
 biological_processGO:0045765 regulation of angiogenesis IDA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050770 regulation of axonogenesis IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IDA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IDA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IEA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IEA
 biological_processGO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0003036 vertebral transformation "homeotic transformation of a specific vertebrae to adopt the fate of another" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kat14tm1a(KOMP)Wtsi/Kat14tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

Allelic Composition: Efna1tm1a(EUCOMM)Wtsi/Efna1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0008825 abnormal cardiac epithelial to mesenchymal transition "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dusp1tm1(KOMP)Wtsi/Dusp1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dusp1tm1(KOMP)Wtsi/Wtsi

Allelic Composition: Efna1tm1a(EUCOMM)Wtsi/Efna1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010344 increased hibernoma incidence "greater than the expected number of a benign neoplasm derived from brown fat occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Efna1tm1a(EUCOMM)Wtsi/Efna1tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0010593 thick aortic valve cusps "an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0010594 thick aortic valve "an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0010617 thick mitral valve cusps 
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0010620 thick mitral valve 
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Plp1jp-rsh/Y
Genetic Background: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr