ENSG00000169242


Homo sapiens

Features
Gene ID: ENSG00000169242
  
Biological name :EFNA1
  
Synonyms : EFNA1 / ephrin A1 / P20827
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 155127460
Gene end: 155134857
  
Corresponding Affymetrix probe sets: 202023_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357391
Ensembl peptide - ENSP00000357392
NCBI entrez gene - 1942     See in Manteia.
OMIM - 191164
RefSeq - NM_004428
RefSeq - NM_182685
RefSeq Peptide - NP_004419
RefSeq Peptide - NP_872626
swissprot - P20827
Ensembl - ENSG00000169242
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna1aENSDARG00000030326Danio rerio
 efna1bENSDARG00000018787Danio rerio
 Efna1ENSMUSG00000027954Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNA3 / P52797 / ephrin A3ENSG0000014359040
AL691442.1ENSG0000025124639
EFNA5 / P52803 / ephrin A5ENSG0000018434938
EFNA2 / O43921 / ephrin A2ENSG0000009961738
EFNA4 / P52798 / ephrin A4ENSG0000024336432


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0003180 aortic valve morphogenesis ISS
 biological_processGO:0003183 mitral valve morphogenesis ISS
 biological_processGO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation ISS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0007411 axon guidance IBA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition ISS
 biological_processGO:0014028 notochord formation IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0033628 regulation of cell adhesion mediated by integrin IDA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0043409 negative regulation of MAPK cascade IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IGI
 biological_processGO:0050730 regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050770 regulation of axonogenesis IEA
 biological_processGO:0050821 protein stabilization IGI
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis ISS
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IGI
 biological_processGO:0070244 negative regulation of thymocyte apoptotic process IEA
 biological_processGO:1902004 positive regulation of amyloid-beta formation IDA
 biological_processGO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IGI
 biological_processGO:1903051 negative regulation of proteolysis involved in cellular protein catabolic process IGI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IBA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046875 ephrin receptor binding IPI


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr