ENSG00000184349


Homo sapiens

Features
Gene ID: ENSG00000184349
  
Biological name :EFNA5
  
Synonyms : EFNA5 / ephrin A5 / P52803
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q21.3
Gene start: 107376889
Gene end: 107670895
  
Corresponding Affymetrix probe sets: 207301_at (Human Genome U133 Plus 2.0 Array)   214036_at (Human Genome U133 Plus 2.0 Array)   227955_s_at (Human Genome U133 Plus 2.0 Array)   233814_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426989
Ensembl peptide - ENSP00000484681
Ensembl peptide - ENSP00000328777
NCBI entrez gene - 1946     See in Manteia.
OMIM - 601535
RefSeq - XM_017009205
RefSeq - NM_001962
RefSeq - XM_006714565
RefSeq - XM_011543250
RefSeq - XM_011543251
RefSeq Peptide - NP_001953
swissprot - D6RDV5
swissprot - A0A087X240
swissprot - P52803
Ensembl - ENSG00000184349
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 efna5aENSDARG00000089790Danio rerio
 EFNA5ENSGALG00000000280Gallus gallus
 Efna5ENSMUSG00000048915Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EFNA2 / O43921 / ephrin A2ENSG0000009961745
EFNA3 / P52797 / ephrin A3ENSG0000014359037
AL691442.1ENSG0000025124636
EFNA1 / P20827 / ephrin A1ENSG0000016924234
EFNA4 / P52798 / ephrin A4ENSG0000024336431


Protein motifs (from Interpro)
Interpro ID Name
 IPR001799  Ephrin receptor-binding domain
 IPR008972  Cupredoxin
 IPR019765  Ephrin, conserved site
 IPR031328  Ephrin
 IPR034252  Ephrin-A ectodomain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation NAS
 biological_processGO:0007171 activation of transmembrane receptor protein tyrosine kinase activity IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0022407 regulation of cell-cell adhesion IEA
 biological_processGO:0022604 regulation of cell morphogenesis IDA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IEA
 biological_processGO:0048668 collateral sprouting IEA
 biological_processGO:0048672 positive regulation of collateral sprouting IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051893 regulation of focal adhesion assembly IDA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IDA
 biological_processGO:0071372 cellular response to follicle-stimulating hormone stimulus IEA
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading IDA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005901 caveola IEA
 cellular_componentGO:0005912 adherens junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane IDA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005168 neurotrophin TRKA receptor binding NAS
 molecular_functionGO:0005169 neurotrophin TRKB receptor binding NAS
 molecular_functionGO:0005170 neurotrophin TRKC receptor binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030297 transmembrane receptor protein tyrosine kinase activator activity NAS
 molecular_functionGO:0045499 chemorepellent activity IEA
 molecular_functionGO:0046875 ephrin receptor binding IEA


Pathways (from Reactome)
Pathway description
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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