ENSDARG00000076179


Danio rerio

Features
Gene ID: ENSDARG00000076179
  
Biological name :ngef
  
Synonyms : neuronal guanine nucleotide exchange factor / ngef
  
Possible biological names infered from orthology : Ephexin-1 / Q8CHT1 / Q8N5V2
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 40074923
Gene end: 40133784
  
Corresponding Affymetrix probe sets: Dr.13054.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000098684
Ensembl peptide - ENSDARP00000128350
NCBI entrez gene - 569090     See in Manteia.
swissprot - E7FDB4
swissprot - X1WDQ1
ZFIN ID - ZDB-GENE-130530-794
Ensembl - ENSDARG00000076179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NGEFENSGALG00000036327Gallus gallus
 NGEFENSG00000066248Homo sapiens
 NgefENSMUSG00000026259Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
arhgef19 / Rho guanine nucleotide exchange factor (GEF) 19 / Q8BWA8* / Q8IW93* / Rho guanine nucleotide exchange factor 19*ENSDARG0000007885331
si:dkey-38p12.3 / O94989* / Q5FWH6* / ARHGEF15* / Rho guanine nucleotide exchange factor 15*ENSDARG0000006184430
arhgef15 / Rho guanine nucleotide exchange factor (GEF) 15 / O94989* / Q5FWH6* / Rho guanine nucleotide exchange factor 15*ENSDARG0000010029328
arhgef16 / Rho guanine nucleotide exchange factor (GEF) 16 / Q3U5C8* / Q5VV41* / Rho guanine nucleotide exchange factor 16*ENSDARG0000007711420
si:ch73-15b2.5ENSDARG0000007946719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex
 ENSDARG00000094673 rhoab / Q6DHM9 / ras homolog gene family, member Ab / RHOA* / Q9QUI0* / P61586* / ras homolog family member A*  / reaction
 ENSDARG00000005941 yes1 / clul1 / A1A5H8 / clusterin-like 1 (retinal) / P07947* / Q04736* / YES proto-oncogene 1, Src family tyrosine kinase*  / complex
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / complex
 ENSDARG00000067916 lyn / LYN proto-oncogene, Src family tyrosine kinase / P07948* / P25911*  / complex
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr