ENSMUSG00000036885


Mus musculus

Features
Gene ID: ENSMUSG00000036885
  
Biological name :Arhgef26
  
Synonyms : Arhgef26 / Rho guanine nucleotide exchange factor (GEF) 26
  
Possible biological names infered from orthology : Q96DR7 / Rho guanine nucleotide exchange factor 26
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 62338344
Gene end: 62462221
  
Corresponding Affymetrix probe sets: 10492341 (MoGene1.0st)   1429185_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078281
Ensembl peptide - ENSMUSP00000124392
NCBI entrez gene - 622434     See in Manteia.
MGI - MGI:1918053
RefSeq - NM_001081295
RefSeq Peptide - NP_001074764
swissprot - F6TAL7
swissprot - D3YYY8
Ensembl - ENSMUSG00000036885
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ARHGEF26ENSGALG00000010352Gallus gallus
 Q96DR7ENSG00000114790Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U5C8 / Arhgef16 / Rho guanine nucleotide exchange factor 16 / Q5VV41*ENSMUSG0000002903237
E9Q7D5 / Arhgef5 / Rho guanine nucleotide exchange factor 5 / Q12774*ENSMUSG0000003354227
Q8BWA8 / Arhgef19 / Rho guanine nucleotide exchange factor 19 / Q8IW93*ENSMUSG0000002891923
Q5FWH6 / Arhgef15 / Rho guanine nucleotide exchange factor 15 / O94989*ENSMUSG0000005292122
Ngef / Q8CHT1 / Ephexin-1 / Q8N5V2* / neuronal guanine nucleotide exchange factor*ENSMUSG0000002625921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035797  ARHGEF16/ARHGEF26, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001886 endothelial cell morphogenesis IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0097178 ruffle assembly IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004003 abnormal vascular endothelial cell physiology "anomaly in the function of the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epxtm1.1(cre)Jlee/Epx+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Epxtm1.1(cre)Jlee/Epx+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Epxtm1.1(cre)Jlee/Epx+,Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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