ENSG00000198844


Homo sapiens

Features
Gene ID: ENSG00000198844
  
Biological name :ARHGEF15
  
Synonyms : ARHGEF15 / O94989 / Rho guanine nucleotide exchange factor 15
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p13.1
Gene start: 8310241
Gene end: 8322516
  
Corresponding Affymetrix probe sets: 205507_at (Human Genome U133 Plus 2.0 Array)   217348_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355026
Ensembl peptide - ENSP00000462796
Ensembl peptide - ENSP00000463875
Ensembl peptide - ENSP00000464540
Ensembl peptide - ENSP00000412505
NCBI entrez gene - 22899     See in Manteia.
OMIM - 608504
RefSeq - XM_011523737
RefSeq - NM_025014
RefSeq - NM_173728
RefSeq - XM_011523734
RefSeq - XM_011523735
RefSeq - XM_011523736
RefSeq Peptide - NP_079290
RefSeq Peptide - NP_776089
swissprot - J3KT46
swissprot - J3QQS4
swissprot - J3QS60
swissprot - O94989
swissprot - A0A0S2Z547
Ensembl - ENSG00000198844
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef15ENSDARG00000100293Danio rerio
 si:dkey-38p12.3ENSDARG00000061844Danio rerio
 Q5FWH6ENSMUSG00000052921Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032729
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263226
NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factorENSG0000006624824
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479023
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0050790 regulation of catalytic activity IDA
 biological_processGO:0051496 positive regulation of stress fiber assembly ISS
 biological_processGO:0061299 retina vasculature morphogenesis in camera-type eye IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:2000297 negative regulation of synapse maturation ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity ISS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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