ENSG00000142632


Homo sapiens

Features
Gene ID: ENSG00000142632
  
Biological name :ARHGEF19
  
Synonyms : ARHGEF19 / Q8IW93 / Rho guanine nucleotide exchange factor 19
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 16197854
Gene end: 16212609
  
Corresponding Affymetrix probe sets: 226857_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000270747
Ensembl peptide - ENSP00000391145
Ensembl peptide - ENSP00000414370
NCBI entrez gene - 128272     See in Manteia.
OMIM - 612496
RefSeq - XM_011540706
RefSeq - NM_153213
RefSeq Peptide - NP_694945
swissprot - Q5TEV0
swissprot - Q8IW93
swissprot - H0Y4D8
Ensembl - ENSG00000142632
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef19ENSDARG00000078853Danio rerio
 Q8BWA8ENSMUSG00000028919Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032743
NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factorENSG0000006624828
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884427
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479026
Q5VV41 / ARHGEF16 / Rho guanine nucleotide exchange factor 16ENSG0000013076224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IGI
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060071 Wnt signaling pathway, planar cell polarity pathway NAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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