ENSG00000130762


Homo sapiens

Features
Gene ID: ENSG00000130762
  
Biological name :ARHGEF16
  
Synonyms : ARHGEF16 / Q5VV41 / Rho guanine nucleotide exchange factor 16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.32
Gene start: 3454426
Gene end: 3481113
  
Corresponding Affymetrix probe sets: 208009_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000367629
Ensembl peptide - ENSP00000411936
Ensembl peptide - ENSP00000390853
Ensembl peptide - ENSP00000367622
Ensembl peptide - ENSP00000367624
NCBI entrez gene - 27237     See in Manteia.
RefSeq - XM_017001049
RefSeq - XM_017001050
RefSeq - XM_017001051
RefSeq - NM_014448
RefSeq Peptide - NP_055263
swissprot - Q5VV41
swissprot - B0QZD3
swissprot - B0QZD4
Ensembl - ENSG00000130762
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef16ENSDARG00000077114Danio rerio
 ARHGEF16ENSGALG00000001058Gallus gallus
 Q3U5C8ENSMUSG00000029032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96DR7 / ARHGEF26 / Rho guanine nucleotide exchange factor 26ENSG0000011479044
Q12774 / ARHGEF5 / Rho guanine nucleotide exchange factor 5ENSG0000005032730
Q8IW93 / ARHGEF19 / Rho guanine nucleotide exchange factor 19ENSG0000014263227
NGEF / Q8N5V2 / neuronal guanine nucleotide exchange factorENSG0000006624827
O94989 / ARHGEF15 / Rho guanine nucleotide exchange factor 15ENSG0000019884425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035797  ARHGEF16/ARHGEF26, SH3 domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0060326 cell chemotaxis IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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