ENSG00000000938


Homo sapiens

Features
Gene ID: ENSG00000000938
  
Biological name :FGR
  
Synonyms : FGR / FGR proto-oncogene, Src family tyrosine kinase / P09769
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p35.3
Gene start: 27612064
Gene end: 27635277
  
Corresponding Affymetrix probe sets: 208438_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407670
Ensembl peptide - ENSP00000363115
Ensembl peptide - ENSP00000363116
Ensembl peptide - ENSP00000363117
Ensembl peptide - ENSP00000382126
NCBI entrez gene - 2268     See in Manteia.
OMIM - 164940
RefSeq - XM_017000674
RefSeq - NM_001042729
RefSeq - NM_001042747
RefSeq - NM_005248
RefSeq - XM_011541011
RefSeq - XM_011541012
RefSeq - XM_011541013
RefSeq - XM_011541014
RefSeq - XM_017000673
RefSeq - XM_006710452
RefSeq - XM_011541010
RefSeq Peptide - NP_001036212
RefSeq Peptide - NP_005239
RefSeq Peptide - NP_001036194
swissprot - P09769
swissprot - Q5TGY6
Ensembl - ENSG00000000938
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FgrENSMUSG00000028874Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinaseENSG0000001081071
YES1 / P07947 / YES proto-oncogene 1, Src family tyrosine kinaseENSG0000017610570
SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinaseENSG0000019712266
HCK / P08631 / HCK proto-oncogene, Src family tyrosine kinaseENSG0000010133655
LYN / P07948 / LYN proto-oncogene, Src family tyrosine kinaseENSG0000025408753
BLK / P51451 / BLK proto-oncogene, Src family tyrosine kinaseENSG0000013657353
LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinaseENSG0000018286652
FRK / P42685 / fyn related Src family tyrosine kinaseENSG0000011181647
SRMS / Q9H3Y6 / src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sitesENSG0000012550838
PTK6 / Q13882 / protein tyrosine kinase 6ENSG0000010121336


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000980  SH2 domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001452  SH3 domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR035693  Tyrosine-protein kinase Fgr, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002768 immune response-regulating cell surface receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
 biological_processGO:0007229 integrin-mediated signaling pathway ISS
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0038083 peptidyl-tyrosine autophosphorylation IBA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043306 positive regulation of mast cell degranulation ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP
 biological_processGO:0045087 innate immune response IBA
 biological_processGO:0045088 regulation of innate immune response ISS
 biological_processGO:0045859 regulation of protein kinase activity ISS
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0050715 positive regulation of cytokine secretion ISS
 biological_processGO:0050764 regulation of phagocytosis ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005758 mitochondrial intermembrane space IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0015629 actin cytoskeleton ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016235 aggresome IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
 cellular_componentGO:0032587 ruffle membrane ISS
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001784 phosphotyrosine residue binding ISS
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISS
 molecular_functionGO:0034987 immunoglobulin receptor binding ISS
 molecular_functionGO:0034988 Fc-gamma receptor I complex binding IDA


Pathways (from Reactome)
Pathway description
FCGR activation
Platelet sensitization by LDL
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000157193 LRP8 / Q14114 / LDL receptor related protein 8  / reaction / complex






 

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