ENSG00000157193


Homo sapiens

Features
Gene ID: ENSG00000157193
  
Biological name :LRP8
  
Synonyms : LDL receptor related protein 8 / LRP8 / Q14114
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p32.3
Gene start: 53242364
Gene end: 53328070
  
Corresponding Affymetrix probe sets: 205282_at (Human Genome U133 Plus 2.0 Array)   208433_s_at (Human Genome U133 Plus 2.0 Array)   228955_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435346
Ensembl peptide - ENSP00000433554
Ensembl peptide - ENSP00000436651
Ensembl peptide - ENSP00000437009
Ensembl peptide - ENSP00000303634
Ensembl peptide - ENSP00000334522
Ensembl peptide - ENSP00000346391
Ensembl peptide - ENSP00000360509
Ensembl peptide - ENSP00000431241
NCBI entrez gene - 7804     See in Manteia.
OMIM - 602600
RefSeq - XM_017002268
RefSeq - XM_005271174
RefSeq - XM_005271175
RefSeq - XM_006710881
RefSeq - XM_006710882
RefSeq - XM_011542094
RefSeq - XM_011542095
RefSeq - XM_011542096
RefSeq - XM_017002265
RefSeq - XM_017002266
RefSeq - XM_017002267
RefSeq - NM_001018054
RefSeq - NM_004631
RefSeq - NM_017522
RefSeq - NM_033300
RefSeq - XM_005271173
RefSeq Peptide - NP_004622
RefSeq Peptide - NP_059992
RefSeq Peptide - NP_150643
RefSeq Peptide - NP_001018064
swissprot - E9PKG2
swissprot - E9PP15
swissprot - Q14114
swissprot - H0YCA4
swissprot - H0YEA5
swissprot - H0YEV6
Ensembl - ENSG00000157193
  
Related genetic diseases (OMIM): 608446 - {Myocardial infarction, susceptibility to}, 608446
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrp8ENSDARG00000070074Danio rerio
 LRP8ENSGALG00000010692Gallus gallus
 Lrp8ENSMUSG00000028613Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VLDLR / P98155 / very low density lipoprotein receptorENSG0000014785245
LDLR / P01130 / low density lipoprotein receptorENSG0000013016444
LRP1 / Q07954 / LDL receptor related protein 1ENSG0000012338435
LRP2 / P98164 / LDL receptor related protein 2ENSG0000008147934
LRP1B / Q9NZR2 / LDL receptor related protein 1BENSG0000016870234
LRP4 / O75096 / LDL receptor related protein 4ENSG0000013456933
LRP6 / O75581 / LDL receptor related protein 6ENSG0000007001817
LRP5 / O75197 / LDL receptor related protein 5ENSG0000016233717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001523 retinoid metabolic process TAS
 biological_processGO:0006508 proteolysis NAS
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway NAS
 biological_processGO:0021541 ammon gyrus development ISS
 biological_processGO:0021987 cerebral cortex development IEA
 biological_processGO:0032793 positive regulation of CREB transcription factor activity ISS
 biological_processGO:0038026 reelin-mediated signaling pathway ISS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0050804 modulation of chemical synaptic transmission ISS
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis ISS
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity ISS
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0071397 cellular response to cholesterol IEA
 biological_processGO:1900006 positive regulation of dendrite development ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043235 receptor complex IDA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005041 low-density lipoprotein particle receptor activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008035 high-density lipoprotein particle binding IEA
 molecular_functionGO:0019894 kinesin binding IEA
 molecular_functionGO:0030229 very-low-density lipoprotein particle receptor activity IDA
 molecular_functionGO:0034185 apolipoprotein binding IC
 molecular_functionGO:0038025 reelin receptor activity ISS


Pathways (from Reactome)
Pathway description
Platelet sensitization by LDL
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000000938 FGR / P09769 / FGR proto-oncogene, Src family tyrosine kinase  / reaction / complex
 ENSG00000130203 APOE / P02649 / apolipoprotein E  / reaction






 

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