ENSMUSG00000022420


Mus musculus

Features
Gene ID: ENSMUSG00000022420
  
Biological name :Dnal4
  
Synonyms : Dnal4 / Dynein light chain 4, axonemal / Q9DCM4
  
Possible biological names infered from orthology : dynein axonemal light chain 4 / O96015
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 79761453
Gene end: 79777849
  
Corresponding Affymetrix probe sets: 10430618 (MoGene1.0st)   1416870_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023055
Ensembl peptide - ENSMUSP00000070325
Ensembl peptide - ENSMUSP00000154848
Ensembl peptide - ENSMUSP00000154908
Ensembl peptide - ENSMUSP00000155613
NCBI entrez gene - 54152     See in Manteia.
MGI - MGI:1859217
RefSeq - NM_017470
RefSeq - XM_006521170
RefSeq Peptide - NP_059498
swissprot - Q8CDT8
swissprot - Q9DCM4
Ensembl - ENSMUSG00000022420
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnal4aENSDARG00000031116Danio rerio
 dnal4bENSDARG00000088841Danio rerio
 DNAL4ENSGALG00000043451Gallus gallus
 DNAL4ENSG00000100246Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dynll1 / P63168 / Dynein light chain 1, cytoplasmic ENSMUSG0000000901328
BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*ENSMUSG0000006406327
Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*ENSMUSG0000002048326


Protein motifs (from Interpro)
Interpro ID Name
 IPR001372  Dynein light chain, type 1/2
 IPR037177  Dynein light chain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0030286 dynein complex IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IBA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0045505 dynein intermediate chain binding IBA
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
Retrograde neurotrophin signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Diaph3tm1b(KOMP)Mbp/Diaph3tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Diaph3tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027859 Ngf / P01139 / Beta-nerve growth factor / P01138* / nerve growth factor*  / reaction
 ENSMUSG00000028488 Q62420 / Sh3gl2 / SH3-domain GRB2-like 2 / Q99962* / SH3 domain containing GRB2 like 2, endophilin A1*  / reaction
 ENSMUSG00000002957 Ap2a2 / P17427 / Mus musculus adaptor-related protein complex 2, alpha 2 subunit (Ap2a2), transcript variant 1, mRNA. / O94973* / adaptor related protein complex 2 alpha 2 subunit*  / reaction
 ENSMUSG00000060279 Ap2a1 / P17426 / AP-2 complex subunit alpha-1 / O95782* / adaptor related protein complex 2 alpha 1 subunit*  / reaction
 ENSMUSG00000022841 Ap2m1 / P84091 / AP-2 complex subunit mu / Q96CW1* / adaptor related protein complex 2 mu 1 subunit*  / reaction
 ENSMUSG00000028072 Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*  / reaction
 ENSMUSG00000035152 Ap2b1 / Q9DBG3 / AP-2 complex subunit beta / P63010* / adaptor related protein complex 2 beta 1 subunit*  / reaction
 ENSMUSG00000008036 Ap2s1 / P62743 / AP-2 complex subunit sigma / P53680* / adaptor related protein complex 2 sigma 1 subunit*  / reaction






 

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