ENSMUSG00000009013


Mus musculus

Features
Gene ID: ENSMUSG00000009013
  
Biological name :Dynll1
  
Synonyms : Dynein light chain 1, cytoplasmic / Dynll1 / P63168
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 115297110
Gene end: 115300999
  
Corresponding Affymetrix probe sets: 10532984 (MoGene1.0st)   10608684 (MoGene1.0st)   1417339_a_at (Mouse Genome 430 2.0 Array)   1440278_at (Mouse Genome 430 2.0 Array)   1448682_at (Mouse Genome 430 2.0 Array)   1456125_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009157
Ensembl peptide - ENSMUSP00000107720
NCBI entrez gene - 56455     See in Manteia.
MGI - MGI:1861457
RefSeq - NM_019682
RefSeq Peptide - NP_062656
swissprot - P63168
Ensembl - ENSMUSG00000009013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dynll1ENSDARG00000058454Danio rerio
 si:dkeyp-51b9.3ENSDARG00000092379Danio rerio
 DYNLL1ENSGALG00000020999Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dynll2 / Q9D0M5 / Dynein light chain 2, cytoplasmic / Q96FJ2* / dynein light chain LC8-type 2*ENSMUSG0000002048393
BC048507 / cDNA sequence BC048507 / DYNLL1* / P63167* / dynein light chain LC8-type 1*ENSMUSG0000006406391
Dnal4 / Q9DCM4 / Dynein light chain 4, axonemal / O96015* / dynein axonemal light chain 4*ENSMUSG0000002242033


Protein motifs (from Interpro)
Interpro ID Name
 IPR001372  Dynein light chain, type 1/2
 IPR019763  Dynein light chain, type 1/2, conserved site
 IPR037177  Dynein light chain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007017 microtubule-based process IEA
 biological_processGO:0035721 intraciliary retrograde transport IMP
 biological_processGO:0042326 negative regulation of phosphorylation ISO
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0044458 motile cilium assembly IMP
 biological_processGO:0045019 negative regulation of nitric oxide biosynthetic process ISO
 biological_processGO:1902857 positive regulation of non-motile cilium assembly IMP
 biological_processGO:2000582 positive regulation of ATP-dependent microtubule motor activity, plus-end-directed IBA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IDA
 cellular_componentGO:0005868 cytoplasmic dynein complex ISO
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005875 microtubule associated complex IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0008180 COP9 signalosome ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0030286 dynein complex IDA
 cellular_componentGO:0072686 mitotic spindle ISS
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0004857 enzyme inhibitor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IBA
 molecular_functionGO:0008574 ATP-dependent microtubule motor activity, plus-end-directed IBA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0045505 dynein intermediate chain binding IPI
 molecular_functionGO:0051959 dynein light intermediate chain binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0001181 absent lungs "missing organs of respiration" [J:51966, J:50768]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ceacam16tm1(KOMP)Wtsi/Ceacam16tm1(KOMP)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6JOlaHsd * C57BL/6N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dbn1tm1a(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1a(KOMP)Wtsi/Wtsi

 MP:0003178 left pulmonary isomerism "bilaterally symmetric left lung pattern (or altered asymmetric patterning of the lung)" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93051]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0004157 interrupted aortic arch "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0004939 abnormal B cell morphology "any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens" [CL:0000236, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Emilin1tm1Gmb/Emilin1tm1Gmb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005262 coloboma "anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0006126 abnormal outflow tract development "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic Background: B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic Background: B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dynll1tm1.1Jhh/Dynll1tm1.1Jhh
Genetic Background: B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dynll1tm1.1Jhh/Dynll1tm1.1Jhh,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd79atm1(cre)Reth/Cd79a+,Dynll1tm1.1Jhh/Dynll1tm1.1Jhh,Tg(IghMyc)22Bri/0
Genetic Background: B6.Cg-Dynll1tm1.1Jhh Cd79atm1(Cre)Reth Tg(IghMyc)22Bri

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dnmt3atm1b(KOMP)Wtsi/Dnmt3atm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnmt3atm1b(KOMP)Wtsi/J

 MP:0011998 decreased embryonic cilium length "reduced length of the cilia of the mouse embryo found on the cells of the embryonic node" [MGI:csmith]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0013203 abnormal primary cilium morphology "any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

 MP:0013213 abnormal embryonic neuroepithelium primary cilium morphology "any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466]
Show

Allelic Composition: Atmingpg6/Atminm1H
Genetic Background: C3.C-Atmingpg6/Atminm1H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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