ENSMUSG00000035305


Mus musculus

Features
Gene ID: ENSMUSG00000035305
  
Biological name :Ror1
  
Synonyms : Inactive tyrosine-protein kinase transmembrane receptor ROR1 / Q9Z139 / Ror1
  
Possible biological names infered from orthology : Q01973 / receptor tyrosine kinase like orphan receptor 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 100095791
Gene end: 100444765
  
Corresponding Affymetrix probe sets: 10506201 (MoGene1.0st)   1429312_s_at (Mouse Genome 430 2.0 Array)   1429313_at (Mouse Genome 430 2.0 Array)   1451014_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048171
NCBI entrez gene - 26563     See in Manteia.
MGI - MGI:1347520
RefSeq - NM_013845
RefSeq Peptide - NP_038873
swissprot - Q9Z139
Ensembl - ENSMUSG00000035305
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ror1ENSDARG00000015176Danio rerio
 ROR1ENSGALG00000011019Gallus gallus
 ROR1ENSG00000185483Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ror2 / Q9Z138 / receptor tyrosine kinase-like orphan receptor 2 / Q01974*ENSMUSG0000002146457
Musk / Q61006 / Muscle, skeletal receptor tyrosine-protein kinase / O15146* / muscle associated receptor tyrosine kinase*ENSMUSG0000005728021
Ntrk2 / P15209 / BDNF/NT-3 growth factors receptor / Q16620* / neurotrophic receptor tyrosine kinase 2*ENSMUSG0000005525420
Igf1r / insulin like growth factor 1 receptor / P08069*ENSMUSG0000000553320
Insr / P15208 / Insulin receptor Insulin receptor subunit alpha Insulin receptor subunit beta / P06213* / insulin receptor*ENSMUSG0000000553419
Ros1 / Q78DX7 / Proto-onco tyrosine-protein kinase ROS / P08922* / ROS proto-oncogene 1, receptor tyrosine kinase*ENSMUSG0000001989318
Ntrk1 / Q3UFB7 / High affinity nerve growth factor receptor / P04629* / neurotrophic receptor tyrosine kinase 1*ENSMUSG0000002807218
Ntrk3 / Q6VNS1 / NT-3 growth factor receptor / Q16288* / neurotrophic receptor tyrosine kinase 3*ENSMUSG0000005914618
Insrr / Q9WTL4 / Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain / P14616* / insulin receptor related receptor*ENSMUSG0000000564018
Alk / P97793 / ALK tyrosine kinase receptor / Q9UM73* / ALK receptor tyrosine kinase*ENSMUSG0000005547118
Ddr2 / Q62371 / Discoidin domain-containing receptor 2 / Q16832* / discoidin domain receptor tyrosine kinase 2*ENSMUSG0000002667417
Ltk / P08923 / Leukocyte tyrosine kinase receptor / P29376* / leukocyte receptor tyrosine kinase*ENSMUSG0000002729716
Ddr1 / Q03146 / Epithelial discoidin domain-containing receptor 1 / Q08345* / discoidin domain receptor tyrosine kinase 1*ENSMUSG0000000353416
Ptk7 / Q8BKG3 / Inactive tyrosine-protein kinase 7 / Q13308* / protein tyrosine kinase 7 (inactive)*ENSMUSG0000002397214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000719  Protein kinase domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR013806  Kringle-like fold
 IPR016247  Tyrosine-protein kinase, receptor ROR
 IPR018056  Kringle, conserved site
 IPR020067  Frizzled domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036790  Frizzled cysteine-rich domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0007605 sensory perception of sound IEA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0043679 axon terminus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0017147 Wnt-protein binding IEA
 molecular_functionGO:0042813 Wnt-activated receptor activity IEA


Pathways (from Reactome)
Pathway description
WNT5A-dependent internalization of FZD2, FZD5 and ROR2


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0000158 absent sternum "missing long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62577]
Show

Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Kat2atm3.1Roth/Kat2atm3.2Roth,Tg(Pcp2-cre)2Mpin/0
Genetic Background: involves: 129

Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ror1tm1.1Meg/Ror1tm1.1Meg,Ror2tm1.1Meg/Ror2tm1.1Meg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hcfc1tm1Lwh/Hcfc1tm1Lwh,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0001967 deafness "inability to hear" [J:57651]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0002622 abnormal cochlear hair cell morphology "malformation of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003148 reduced cochlear coiling "a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns" [J:56294, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0004110 transposition of great arteries "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ror1tm1.1Meg/Ror1tm1.1Meg,Ror2tm1.1Meg/Ror2tm1.1Meg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004506 abnormal pubic bone morphology "any structural anomaly in the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004736 abnormal distortion product otoacoustic emission "any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009284 abnormal sympathetic neuron innervation "defective or incomplete supply of nerve fibers to sympathetic termini" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009538 abnormal synapse morphology "any strucutral anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.850]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0009666 abnormal embryo attachment "any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:10882512 "Carson DD, et al, Embryo implantation Dev Biol. 2000 Jul 15;223(2):217-37."]
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Allelic Composition: Pgrtm2(cre)Lyd/Pgr+,Ror1tm1.1Meg/Ror1tm1.1Meg,Ror2tm1.1Meg/Ror2tm1.1Meg
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Igf1rtm1Arge/Igf1rtm2Arge,Tg(Camk2a-cre)2Szi/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Ror1tm1Ymi/Ror1tm1Ymi,Ror2tm1Ymi/Ror2tm1Ymi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Ror1tm1.2Meg/Ror1tm1.2Meg,Ror2tm1.2Meg/Ror2tm1.2Meg
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0020359 abnormal ribbon synapse morphology "any structural anomaly in a synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm" [GO:0097470]
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Allelic Composition: Blvratm1c(EUCOMM)Hmgu/Blvratm1c(EUCOMM)Hmgu,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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