ENSMUSG00000054667


Mus musculus

Features
Gene ID: ENSMUSG00000054667
  
Biological name :Irs4
  
Synonyms : Insulin receptor substrate 4 / Irs4 / Q9Z0Y7
  
Possible biological names infered from orthology : O14654
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F2
Gene start: 141710998
Gene end: 141725263
  
Corresponding Affymetrix probe sets: 10607059 (MoGene1.0st)   1422248_at (Mouse Genome 430 2.0 Array)   1441429_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067085
NCBI entrez gene - 16370     See in Manteia.
MGI - MGI:1338009
RefSeq - NM_010572
RefSeq Peptide - NP_034702
swissprot - Q9Z0Y7
Ensembl - ENSMUSG00000054667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IRS4ENSG00000133124Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*ENSMUSG0000003889425
Irs1 / insulin receptor substrate 1 / P35568*ENSMUSG0000005598024
Irs3ENSMUSG0000004718212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005158 insulin receptor binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IBA


Pathways (from Reactome)
Pathway description
IRS-related events triggered by IGF1R


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pdgfratm1Sor/Pdgfratm1Sor
Genetic Background: either: 129S4/SvJaeSor-Pdgfratm1Sor or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Y
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs4tm1Lhd/Irs4tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ddhd1tm1b(KOMP)Katn/Ddhd1tm1b(KOMP)Katn
Genetic Background: involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj

Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

 MP:0020234 decreased basal metabolism "decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state" [GOC:NV]
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Allelic Composition: Irs2tm2Mfw/Irs2tm2Mfw,Irs4tm1.1Mfw/Y,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction / complex
 ENSMUSG00000005533 Igf1r / insulin like growth factor 1 receptor / P08069*  / reaction / complex
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction / complex






 

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