ENSMUSG00000047182


Mus musculus

Features
Gene ID: ENSMUSG00000047182
  
Biological name :Irs3
  
Synonyms : Irs3
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 137643031
Gene end: 137645714
  
Corresponding Affymetrix probe sets: 10534883 (MoGene1.0st)   1437672_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060844
Ensembl peptide - ENSMUSP00000142730
NCBI entrez gene - 16369     See in Manteia.
MGI - MGI:1194882
RefSeq - NM_010571
RefSeq Peptide - NP_034701
swissprot - O54718
swissprot - Q4QQK2
Ensembl - ENSMUSG00000047182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 irs2aENSDARG00000037099Danio rerio
 irs2bENSDARG00000075282Danio rerio
 IRS2ENSGALG00000026287Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Irs1 / insulin receptor substrate 1 / P35568*ENSMUSG0000005598035
Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*ENSMUSG0000003889434
Irs4 / Q9Z0Y7 / Insulin receptor substrate 4 / O14654*ENSMUSG0000005466730


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR002404  IRS-type PTB domain
 IPR011993  PH-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IBA
 molecular_functionGO:0005158 insulin receptor binding IBA
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Irs4tm1Lhd/Y
Genetic Background: involves: 129S4/SvJae * BALB/c

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Irs1tm1Tka/Irs1tm1Tka
Genetic Background: Not Specified

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Irs1tm1Jos/Irs1tm1Jos,Irs3tm1Lhd/Irs3tm1Lhd
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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