ENSG00000178732


Homo sapiens

Features
Gene ID: ENSG00000178732
  
Biological name :GP5
  
Synonyms : glycoprotein V platelet / GP5 / P40197
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q29
Gene start: 194394821
Gene end: 194398354
  
Corresponding Affymetrix probe sets: 207926_at (Human Genome U133 Plus 2.0 Array)   211525_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383931
NCBI entrez gene - 2814     See in Manteia.
OMIM - 173511
RefSeq - NM_004488
RefSeq Peptide - NP_004479
swissprot - P40197
Ensembl - ENSG00000178732
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-117l17.7ENSDARG00000100217Danio rerio
 GP5ENSGALG00000045125Gallus gallus
 Gp5ENSMUSG00000047953Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC15 / Q8TF66 / leucine rich repeat containing 15ENSG0000017206131
CPN2 / P22792 / carboxypeptidase N subunit 2ENSG0000017877228
IGFALS / P35858 / insulin like growth factor binding protein acid labile subunitENSG0000009976925
TRIL / Q7L0X0 / TLR4 interactor with leucine rich repeatsENSG0000025569024
CHADL / Q6NUI6 / chondroadherin likeENSG0000010039924
NYX / Q9GZU5 / nyctalopinENSG0000018893721
LRRTM4 / Q86VH4 / leucine rich repeat transmembrane neuronal 4ENSG0000017620420
LRRC70 / Q7Z2Q7 / leucine rich repeat containing 70ENSG0000018610520
LRRTM2 / O43300 / leucine rich repeat transmembrane neuronal 2ENSG0000014600619
LRRTM3 / Q86VH5 / leucine rich repeat transmembrane neuronal 3ENSG0000019873918
LRRTM1 / Q86UE6 / leucine rich repeat transmembrane neuronal 1ENSG0000016295118
CHAD / O15335 / chondroadherinENSG0000013645715


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0007409 axonogenesis IBA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0007597 blood coagulation, intrinsic pathway TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0030168 platelet activation TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000131187 F12 / P00748 / coagulation factor XII  / reaction
 ENSG00000180210 F2 / P00734 / coagulation factor II, thrombin  / reaction / complex
 ENSG00000145675 P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1  / reaction / complex
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / reaction / complex
 ENSG00000101981 F9 / P00740 / coagulation factor IX  / reaction
 ENSG00000088926 F11 / P03951 / coagulation factor XI  / reaction / complex
 ENSG00000203618 GP1BB / P13224 / glycoprotein Ib platelet beta subunit  / complex
 ENSG00000169704 GP9 / P14770 / glycoprotein IX platelet  / complex
 ENSG00000110799 VWF / P04275 / von Willebrand factor  / reaction / complex
 ENSG00000196924 FLNA / P21333 / filamin A  / reaction / complex
 ENSG00000185245 GP1BA / P07359 / glycoprotein Ib platelet alpha subunit  / complex






 

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