ENSG00000178772


Homo sapiens

Features
Gene ID: ENSG00000178772
  
Biological name :CPN2
  
Synonyms : carboxypeptidase N subunit 2 / CPN2 / P22792
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q29
Gene start: 194339765
Gene end: 194351328
  
Corresponding Affymetrix probe sets: 216223_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000319464
Ensembl peptide - ENSP00000402232
NCBI entrez gene - 1370     See in Manteia.
OMIM - 603104
RefSeq - XM_005269280
RefSeq - NM_001080513
RefSeq - NM_001291988
RefSeq Peptide - NP_001278917
RefSeq Peptide - NP_001073982
swissprot - P22792
Ensembl - ENSG00000178772
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:153913ENSDARG00000063518Danio rerio
 CPN2ENSGALG00000045776Gallus gallus
 Cpn2ENSMUSG00000023176Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LRRC15 / Q8TF66 / leucine rich repeat containing 15ENSG0000017206129
GP5 / P40197 / glycoprotein V plateletENSG0000017873229
IGFALS / P35858 / insulin like growth factor binding protein acid labile subunitENSG0000009976926
TRIL / Q7L0X0 / TLR4 interactor with leucine rich repeatsENSG0000025569026
CHADL / Q6NUI6 / chondroadherin likeENSG0000010039925
LRRC70 / Q7Z2Q7 / leucine rich repeat containing 70ENSG0000018610523
NYX / Q9GZU5 / nyctalopinENSG0000018893720
LRRTM4 / Q86VH4 / leucine rich repeat transmembrane neuronal 4ENSG0000017620419
LRRTM3 / Q86VH5 / leucine rich repeat transmembrane neuronal 3ENSG0000019873919
LRRTM2 / O43300 / leucine rich repeat transmembrane neuronal 2ENSG0000014600618
LRRTM1 / Q86UE6 / leucine rich repeat transmembrane neuronal 1ENSG0000016295116
CHAD / O15335 / chondroadherinENSG0000013645716


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0050790 regulation of catalytic activity IEA
 biological_processGO:0050821 protein stabilization NAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004181 metallocarboxypeptidase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030234 enzyme regulator activity NAS


Pathways (from Reactome)
Pathway description
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125730 C3 / P01024 / complement C3  / reaction
 ENSG00000178772 CPN2 / P22792 / carboxypeptidase N subunit 2  / complex
 ENSG00000106804 C5 / P01031 / complement C5  / reaction
 ENSG00000120054 CPN1 / P15169 / carboxypeptidase N subunit 1  / complex






 

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