ENSMUSG00000050761


Mus musculus

Features
Gene ID: ENSMUSG00000050761
  
Biological name :Gp1bb
  
Synonyms : glycoprotein Ib, beta polypeptide / Gp1bb / P56400
  
Possible biological names infered from orthology : glycoprotein Ib platelet beta subunit / P13224
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A3
Gene start: 18620319
Gene end: 18622403
  
Corresponding Affymetrix probe sets: 1422977_at (Mouse Genome 430 2.0 Array)   1452357_at (Mouse Genome 430 2.0 Array)   1456427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000059270
Ensembl peptide - ENSMUSP00000126292
NCBI entrez gene - 14724     See in Manteia.
MGI - MGI:107852
RefSeq - NM_001001999
RefSeq - NM_010327
RefSeq Peptide - NP_001001999
RefSeq Peptide - NP_034457
swissprot - P56400
swissprot - B2RR03
Ensembl - ENSMUSG00000050761
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gp1bbENSDARG00000074441Danio rerio
 GP1BBENSGALG00000021529Gallus gallus
 GP1BBENSG00000203618Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*ENSMUSG0000003005428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion ISS
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002599 increased mean platelet volume "increased content of platelet cells over the norm" [cml:Cathleen M. Lutz, Mouse Genome Informatics Curator]
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Allelic Composition: Ddb2tm1Pra/Ddb2+
Genetic Background: involves: C57BL/6

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ddb2tm1Pra/Ddb2+
Genetic Background: involves: C57BL/6

Allelic Composition: Gp1bbtm1Ware/Gp1bb+
Genetic Background: Not Specified

Allelic Composition: Gp1bbtm1Frla/Gp1bbtm1Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004720 abnormal platelet morphology "any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Gp1bbtm1Frla/Gp1bbtm1Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdss2kd/Pdss2kd
Genetic Background: involves: C57BL/6 * CBA/H

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ddb2tm1Pra/Ddb2+
Genetic Background: involves: C57BL/6

Allelic Composition: Gp1bbtm1Frla/Gp1bbtm1Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021492 F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*  / reaction
 ENSMUSG00000031328 Flna / Q8BTM8 / Filamin-A / P21333*  / reaction / complex
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction / complex
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / complex
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / complex
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / reaction / complex
 ENSMUSG00000031645 F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / complex
 ENSMUSG00000031138 F9 / P16294 / Coagulation factor IX Coagulation factor IXa light chain Coagulation factor IXa heavy chain / P00740* / coagulation factor IX*  / reaction
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / complex






 

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