ENSMUSG00000021492


Mus musculus

Features
Gene ID: ENSMUSG00000021492
  
Biological name :F12
  
Synonyms : Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / F12 / Q80YC5
  
Possible biological names infered from orthology : coagulation factor XII / P00748
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B1
Gene start: 55417958
Gene end: 55426793
  
Corresponding Affymetrix probe sets: 10409449 (MoGene1.0st)   1420496_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000125771
Ensembl peptide - ENSMUSP00000021948
NCBI entrez gene - 58992     See in Manteia.
MGI - MGI:1891012
RefSeq - NM_021489
RefSeq Peptide - NP_067464
swissprot - E9Q698
swissprot - Q80YC5
Ensembl - ENSMUSG00000021492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 F12ENSG00000131187Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hgfac / Q9R098 / hepatocyte growth factor activator / Q04756* / HGF activator*ENSMUSG0000002910240
Habp2 / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA. / Q14520* / hyaluronan binding protein 2*ENSMUSG0000002507528
Plat / P11214 / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B / P00750* / plasminogen activator, tissue type*ENSMUSG0000003153828
Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*ENSMUSG0000005948127
Plau / P06869 / plasminogen activator, urokinase / P00749*ENSMUSG0000002182225
Hgf / Q08048 / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain / P14210* / hepatocyte growth factor*ENSMUSG0000002886424
Mst1 / P26928 / macrophage stimulating 1 (hepatocyte growth factor-like) / macrophage stimulating 1*ENSMUSG0000003259123
F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*ENSMUSG0000002724920


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000083  Fibronectin, type I
 IPR000562  Fibronectin type II domain
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR001881  EGF-like calcium-binding domain
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR013806  Kringle-like fold
 IPR014394  Coagulation factor XII/hepatocyte growth factor activator
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002353 plasma kallikrein-kinin cascade IEA
 biological_processGO:0002542 Factor XII activation IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010756 positive regulation of plasminogen activation IEA
 biological_processGO:0016485 protein processing IEA
 biological_processGO:0016540 protein autoprocessing IEA
 biological_processGO:0030193 regulation of blood coagulation IMP
 biological_processGO:0030194 positive regulation of blood coagulation IEA
 biological_processGO:0031638 zymogen activation IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0051788 response to misfolded protein IEA
 biological_processGO:0051919 positive regulation of fibrinolysis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008233 peptidase activity IMP
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hba/Nprl3tm1.1Wgw/Hba/Nprl3tm1.1Wgw
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003075 response to CNS ischemic injury 
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Allelic Composition: Hba/Nprl3tm1.1Wgw/Hba/Nprl3tm1.1Wgw
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hba/Nprl3tm1.1Wgw/Hba/Nprl3tm1.1Wgw
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0009812 abnormal bradykinin level "abnormal concentration of a potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability" [ISBN:0-397-51047-0 "Rubin E, et al. Pathology, 2nd edition"]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0012359 increased partial thromboplastin time "increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways" [MPD:Molly]
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Allelic Composition: Sox11tm1.1Gan/Sox11tm1.1Gan,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000109764 Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*  / reaction
 ENSMUSG00000023224 P97290 / Serping1 / serine (or cysteine) peptidase inhibitor, clade G, member 1 / P05155* / serpin family G member 1*  / reaction / complex
 ENSMUSG00000031645 F11 / Q91Y47 / Coagulation factor XI Coagulation factor XIa heavy chain Coagulation factor XIa light chain / P03951* / coagulation factor XI*  / reaction
 ENSMUSG00000050761 Gp1bb / P56400 / glycoprotein Ib, beta polypeptide / P13224* / glycoprotein Ib platelet beta subunit*  / reaction
 ENSMUSG00000030054 Gp9 / O88186 / glycoprotein 9 (platelet) / P14770* / glycoprotein IX platelet*  / reaction
 ENSMUSG00000047953 Gp5 / glycoprotein V platelet / P40197*  / reaction
 ENSMUSG00000050675 Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*  / reaction
 ENSMUSG00000021492 F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*  / complex
 ENSMUSG00000018446 C1qbp / complement C1q binding protein / Q07021*  / reaction






 

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