Manteia

ENSMUSG00000018446

Mus musculus

Features

Gene ID:	ENSMUSG00000018446

Biological name :	C1qbp

Synonyms :	C1qbp / complement C1q binding protein

Possible biological names infered from orthology :	Q07021

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B4
Gene start:	70977836
Gene end:	70983026

Corresponding Affymetrix probe sets:	10388010 (MoGene1.0st) 1448274_at (Mouse Genome 430 2.0 Array) 1455821_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000077612 NCBI entrez gene - 12261 See in Manteia. MGI - MGI:1194505 RefSeq - NM_007573 RefSeq Peptide - NP_031599 swissprot - Q8R5L1 Ensembl - ENSMUSG00000018446

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
c1qbp	ENSDARG00000039887	Danio rerio
C1QBP	ENSGALG00000001654	Gallus gallus
C1QBP	ENSG00000108561	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003428	Mitochondrial glycoprotein
IPR036561	Mitochondrial glycoprotein superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IEA
biological_process	GO:0014065	phosphatidylinositol 3-kinase signaling	IEA
biological_process	GO:0030449	regulation of complement activation	IEA
biological_process	GO:0032689	negative regulation of interferon-gamma production	IEA
biological_process	GO:0032695	negative regulation of interleukin-12 production	IEA
biological_process	GO:0039534	negative regulation of MDA-5 signaling pathway	IEA
biological_process	GO:0039536	negative regulation of RIG-I signaling pathway	IEA
biological_process	GO:0042256	mature ribosome assembly	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IEA
biological_process	GO:0045785	positive regulation of cell adhesion	IEA
biological_process	GO:0048025	negative regulation of mRNA splicing, via spliceosome	IEA
biological_process	GO:0050687	negative regulation of defense response to virus	IEA
biological_process	GO:0051897	positive regulation of protein kinase B signaling	IEA
biological_process	GO:0090023	positive regulation of neutrophil chemotaxis	IEA
biological_process	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IEA
biological_process	GO:1901165	positive regulation of trophoblast cell migration	IEA
biological_process	GO:2000510	positive regulation of dendritic cell chemotaxis	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IEA
cellular_component	GO:0005759	mitochondrial matrix	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
molecular_function	GO:0001849	complement component C1q binding	IEA
molecular_function	GO:0003714	transcription corepressor activity	IEA
molecular_function	GO:0005080	protein kinase C binding	IEA
molecular_function	GO:0005540	hyaluronic acid binding	IEA
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0030984	kininogen binding	IEA
molecular_function	GO:0031690	adrenergic receptor binding	IEA

Pathways (from Reactome)

Pathway description

Intrinsic Pathway of Fibrin Clot Formation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000352	decreased cell proliferation	"less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0010955	abnormal respiratory electron transport chain	"anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Gpm6b^tm1Kan/Gpm6b⁺,Plp1^tm1Kan/Plp1^tm1Kan Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000109764	Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*	/ reaction / complex
ENSMUSG00000061119	Prcp / Q7TMR0 / Lysosomal Pro-X carboxypeptidase / P42785* / prolylcarboxypeptidase*	/ reaction
ENSMUSG00000021492	F12 / Q80YC5 / Coagulation factor XII Coagulation factor XIIa heavy chain Coagulation factor XIIa light chain / P00748* / coagulation factor XII*	/ reaction
ENSMUSG00000018446	C1qbp / complement C1q binding protein / Q07021*	/ complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr