ENSMUSG00000061119


Mus musculus

Features
Gene ID: ENSMUSG00000061119
  
Biological name :Prcp
  
Synonyms : Lysosomal Pro-X carboxypeptidase / Prcp / Q7TMR0
  
Possible biological names infered from orthology : P42785 / prolylcarboxypeptidase
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E1
Gene start: 92874470
Gene end: 92934583
  
Corresponding Affymetrix probe sets: 10554945 (MoGene1.0st)   1431361_at (Mouse Genome 430 2.0 Array)   1444419_at (Mouse Genome 430 2.0 Array)   1452190_at (Mouse Genome 430 2.0 Array)   1452191_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146597
Ensembl peptide - ENSMUSP00000075429
NCBI entrez gene - 72461     See in Manteia.
MGI - MGI:1919711
RefSeq - NM_028243
RefSeq Peptide - NP_082519
swissprot - A0A140LHY2
swissprot - Q7TMR0
Ensembl - ENSMUSG00000061119
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prcpENSDARG00000037883Danio rerio
 PRCPENSGALG00000037521Gallus gallus
 PRCPENSG00000137509Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpp7 / Q9ET22 / Dipeptidyl peptidase 2 / Q9UHL4* / dipeptidyl peptidase 7*ENSMUSG0000002695838
Prss16 / Q9QXE5 / protease, serine 16 (thymus) / Q9NQE7* / serine protease 16*ENSMUSG0000000617923


Protein motifs (from Interpro)
Interpro ID Name
 IPR008758  Peptidase S28
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IMP
 biological_processGO:0002353 plasma kallikrein-kinin cascade IMP
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration ISO
 biological_processGO:0060055 angiogenesis involved in wound healing IMP
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0045178 basal part of cell IDA
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009291 decreased femoral fat pad weight 
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009299 decreased mesenteric fat pad weight 
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009305 decreased retroperitoneal fat pad weight 
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Jag1Gt(betageo)1Byg/Jag1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000109764 Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*  / reaction
 ENSMUSG00000018446 C1qbp / complement C1q binding protein / Q07021*  / reaction
 ENSMUSG00000061119 Prcp / Q7TMR0 / Lysosomal Pro-X carboxypeptidase / P42785* / prolylcarboxypeptidase*  / complex






 

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