ENSMUSG00000006179


Mus musculus

Features
Gene ID: ENSMUSG00000006179
  
Biological name :Prss16
  
Synonyms : protease, serine 16 (thymus) / Prss16 / Q9QXE5
  
Possible biological names infered from orthology : Q9NQE7 / serine protease 16
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A3.1
Gene start: 22002173
Gene end: 22009742
  
Corresponding Affymetrix probe sets: 10408097 (MoGene1.0st)   1448355_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152943
Ensembl peptide - ENSMUSP00000006341
NCBI entrez gene - 54373     See in Manteia.
MGI - MGI:1859181
RefSeq - NM_019429
RefSeq Peptide - NP_062302
swissprot - A0A286YCE6
swissprot - Q5SZ30
swissprot - Q9QXE5
Ensembl - ENSMUSG00000006179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prss16ENSDARG00000076602Danio rerio
 PRSS16ENSG00000112812Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dpp7 / Q9ET22 / Dipeptidyl peptidase 2 / Q9UHL4* / dipeptidyl peptidase 7*ENSMUSG0000002695826
Prcp / Q7TMR0 / Lysosomal Pro-X carboxypeptidase / P42785* / prolylcarboxypeptidase*ENSMUSG0000006111922


Protein motifs (from Interpro)
Interpro ID Name
 IPR008758  Peptidase S28
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Spout1tm1Mxu/Spout1+,Dffatm1Mxu/Dffatm1Mxu
Genetic Background: involves: 129 * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kitlsl-du/Kitlsl-du
Genetic Background: C3H/HeJ-Kitlsl-du

 MP:0004919 abnormal positive T cell selection "any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death" [GO:0043368]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Prss16tm1Mal/Prss16+,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Prss16tm1Mal/Prss16+,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Prss16tm1Mal/Prss16+,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008101 lymph node hypoplasia "underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prss16tm1Mal/Prss16tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

Allelic Composition: Prss16tm1Mal/Prss16+,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0008195 abnormal antigen presenting cell morphology "any structural anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response" [CL:0000145, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kitlsl-du/Kitlsl-du
Genetic Background: C3H/HeJ-Kitlsl-du

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr