ENSG00000137509


Homo sapiens

Features
Gene ID: ENSG00000137509
  
Biological name :PRCP
  
Synonyms : P42785 / PRCP / prolylcarboxypeptidase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.1
Gene start: 82823502
Gene end: 82970584
  
Corresponding Affymetrix probe sets: 1569205_at (Human Genome U133 Plus 2.0 Array)   201494_at (Human Genome U133 Plus 2.0 Array)   231588_at (Human Genome U133 Plus 2.0 Array)   242636_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000377055
Ensembl peptide - ENSP00000317362
Ensembl peptide - ENSP00000437169
Ensembl peptide - ENSP00000436141
Ensembl peptide - ENSP00000436095
Ensembl peptide - ENSP00000435071
Ensembl peptide - ENSP00000434771
Ensembl peptide - ENSP00000432506
Ensembl peptide - ENSP00000432004
Ensembl peptide - ENSP00000431559
Ensembl peptide - ENSP00000431496
Ensembl peptide - ENSP00000431435
NCBI entrez gene - 5547     See in Manteia.
OMIM - 176785
RefSeq - NM_199418
RefSeq - NM_001319214
RefSeq - XM_005274093
RefSeq - NM_005040
RefSeq Peptide - NP_005031
RefSeq Peptide - NP_001306143
RefSeq Peptide - NP_955450
swissprot - E9PL49
swissprot - E9PKN6
swissprot - E9PR42
swissprot - A0A024R5L0
swissprot - P42785
swissprot - E9PIG4
swissprot - E9PQN3
swissprot - E9PQB5
swissprot - E9PNJ1
swissprot - E9PNF7
swissprot - E9PLY4
swissprot - E9PL85
Ensembl - ENSG00000137509
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prcpENSDARG00000037883Danio rerio
 PRCPENSGALG00000037521Gallus gallus
 PrcpENSMUSG00000061119Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DPP7 / Q9UHL4 / dipeptidyl peptidase 7ENSG0000017697838
PRSS16 / Q9NQE7 / serine protease 16ENSG0000011281222


Protein motifs (from Interpro)
Interpro ID Name
 IPR008758  Peptidase S28
 IPR029058  Alpha/Beta hydrolase fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002155 regulation of thyroid hormone mediated signaling pathway IEA
 biological_processGO:0002353 plasma kallikrein-kinin cascade IEA
 biological_processGO:0003085 negative regulation of systemic arterial blood pressure IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007597 blood coagulation, intrinsic pathway TAS
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043535 regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0097009 energy homeostasis IEA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0004180 carboxypeptidase activity IEA
 molecular_functionGO:0004185 serine-type carboxypeptidase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0008239 dipeptidyl-peptidase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164344 KLKB1 / P03952 / kallikrein B1  / reaction
 ENSG00000137509 PRCP / P42785 / prolylcarboxypeptidase  / complex
 ENSG00000108561 C1QBP / Q07021 / complement C1q binding protein  / reaction
 ENSG00000113889 KNG1 / P01042 / kininogen 1  / reaction






 

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