ENSG00000108561


Homo sapiens

Features
Gene ID: ENSG00000108561
  
Biological name :C1QBP
  
Synonyms : C1QBP / complement C1q binding protein / Q07021
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.2
Gene start: 5432777
Gene end: 5448830
  
Corresponding Affymetrix probe sets: 208910_s_at (Human Genome U133 Plus 2.0 Array)   214214_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460308
Ensembl peptide - ENSP00000460638
Ensembl peptide - ENSP00000225698
Ensembl peptide - ENSP00000458624
NCBI entrez gene - 708     See in Manteia.
OMIM - 601269
RefSeq - NM_001212
RefSeq Peptide - NP_001203
swissprot - A0A0G2JLC0
swissprot - I3L3B0
swissprot - I3L3Q7
swissprot - Q07021
Ensembl - ENSG00000108561
  
Related genetic diseases (OMIM): 617713 - Combined oxidative phosphorylation deficiency 33, 617713
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c1qbpENSDARG00000039887Danio rerio
 C1QBPENSGALG00000001654Gallus gallus
 C1qbpENSMUSG00000018446Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003428  Mitochondrial glycoprotein
 IPR036561  Mitochondrial glycoprotein superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0007597 blood coagulation, intrinsic pathway TAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030449 regulation of complement activation IDA
 biological_processGO:0032689 negative regulation of interferon-gamma production IDA
 biological_processGO:0032695 negative regulation of interleukin-12 production IDA
 biological_processGO:0039534 negative regulation of MDA-5 signaling pathway IDA
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IDA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042256 mature ribosome assembly IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045785 positive regulation of cell adhesion IMP
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 biological_processGO:0050687 negative regulation of defense response to virus IMP
 biological_processGO:0051897 positive regulation of protein kinase B signaling IMP
 biological_processGO:0070131 positive regulation of mitochondrial translation ISS
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IDA
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
 biological_processGO:1901165 positive regulation of trophoblast cell migration IMP
 biological_processGO:2000510 positive regulation of dendritic cell chemotaxis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005759 mitochondrial matrix IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0001849 complement component C1q binding IDA
 molecular_functionGO:0003714 transcription corepressor activity IDA
 molecular_functionGO:0003729 mRNA binding ISS
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005540 hyaluronic acid binding IDA
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0030984 kininogen binding IDA
 molecular_functionGO:0031690 adrenergic receptor binding IEA
 molecular_functionGO:0097177 mitochondrial ribosome binding ISS


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108561 C1QBP / Q07021 / complement C1q binding protein  / complex
 ENSG00000113889 KNG1 / P01042 / kininogen 1  / complex / reaction
 ENSG00000131187 F12 / P00748 / coagulation factor XII  / reaction
 ENSG00000164344 KLKB1 / P03952 / kallikrein B1  / complex / reaction
 ENSG00000137509 PRCP / P42785 / prolylcarboxypeptidase  / reaction






 

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