ENSG00000113889


Homo sapiens

Features
Gene ID: ENSG00000113889
  
Biological name :KNG1
  
Synonyms : kininogen 1 / KNG1 / P01042
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q27.3
Gene start: 186717276
Gene end: 186744410
  
Corresponding Affymetrix probe sets: 206054_at (Human Genome U133 Plus 2.0 Array)   217512_at (Human Genome U133 Plus 2.0 Array)   243562_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000287611
Ensembl peptide - ENSP00000493985
Ensembl peptide - ENSP00000496167
Ensembl peptide - ENSP00000265023
Ensembl peptide - ENSP00000396025
NCBI entrez gene - 3827     See in Manteia.
OMIM - 612358
RefSeq - NM_000893
RefSeq - NM_001102416
RefSeq - NM_001166451
RefSeq Peptide - NP_000884
RefSeq Peptide - NP_001095886
RefSeq Peptide - NP_001159923
swissprot - P01042
Ensembl - ENSG00000113889
  
Related genetic diseases (OMIM): 228960 - [High molecular weight kininogen deficiency], 228960
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kng1ENSDARG00000022372Danio rerio
 KNG1ENSGALG00000046159Gallus gallus
 Kng1ENSMUSG00000022875Mus musculus
 Kng2ENSMUSG00000060459Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR002395  HMW kininogen
 IPR018073  Proteinase inhibitor I25, cystatin, conserved site
 IPR027358  Kininogen-type cystatin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007162 negative regulation of cell adhesion IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007597 blood coagulation, intrinsic pathway TAS
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030195 negative regulation of blood coagulation IDA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043065 positive regulation of apoptotic process NAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045861 negative regulation of proteolysis IDA
 biological_processGO:0050880 regulation of blood vessel size IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0072562 blood microparticle HDA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008201 heparin binding NAS
 molecular_functionGO:0008270 zinc ion binding NAS
 molecular_functionGO:0030414 peptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108561 C1QBP / Q07021 / complement C1q binding protein  / complex / reaction
 ENSG00000100739 BDKRB1 / P46663 / bradykinin receptor B1  / complex / reaction
 ENSG00000113889 KNG1 / P01042 / kininogen 1  / complex
 ENSG00000131187 F12 / P00748 / coagulation factor XII  / reaction
 ENSG00000168398 BDKRB2 / P30411 / bradykinin receptor B2  / reaction / complex
 ENSG00000164344 KLKB1 / P03952 / kallikrein B1  / reaction / complex
 ENSG00000137509 PRCP / P42785 / prolylcarboxypeptidase  / reaction






 

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