ENSG00000168398


Homo sapiens

Features
Gene ID: ENSG00000168398
  
Biological name :BDKRB2
  
Synonyms : BDKRB2 / bradykinin receptor B2 / P30411
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 96204679
Gene end: 96244166
  
Corresponding Affymetrix probe sets: 205870_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450482
Ensembl peptide - ENSP00000438376
Ensembl peptide - ENSP00000439459
NCBI entrez gene - 624     See in Manteia.
OMIM - 113503
RefSeq - NM_000623
RefSeq Peptide - NP_000614
swissprot - P30411
Ensembl - ENSG00000168398
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-63b1.1ENSDARG00000043664Danio rerio
 BDKRB2ENSGALG00000011080Gallus gallus
 Bdkrb2ENSMUSG00000021070Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BDKRB1 / P46663 / bradykinin receptor B1ENSG0000010073932
AGTR2 / P50052 / angiotensin II receptor type 2ENSG0000018077226
AGTR1 / P30556 / angiotensin II receptor type 1ENSG0000014489126
APLNR / P35414 / apelin receptorENSG0000013481723
RXFP3 / Q9NSD7 / relaxin/insulin like family peptide receptor 3ENSG0000018263122
GPR25 / O00155 / G protein-coupled receptor 25ENSG0000017012822
RXFP4 / Q8TDU9 / relaxin/insulin like family peptide receptor 4ENSG0000017308020
GPR182 / O15218 / G protein-coupled receptor 182ENSG0000016685620
GPR15 / P49685 / G protein-coupled receptor 15ENSG0000015416520
ACKR3 / P25106 / atypical chemokine receptor 3ENSG0000014447620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000496  Bradykinin receptor family
 IPR001504  Bradykinin receptor B2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006939 smooth muscle contraction IC
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0006954 inflammatory response IC
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0008015 blood circulation NAS
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0019229 regulation of vasoconstriction IC
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042311 vasodilation IEA
 biological_processGO:0043114 regulation of vascular permeability IC
 biological_processGO:0050482 arachidonic acid secretion IDA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IEA
 biological_processGO:1902239 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IEA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004947 bradykinin receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IPI
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000113889 KNG1 / P01042 / kininogen 1  / reaction / complex






 

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