ENSG00000180772


Homo sapiens

Features
Gene ID: ENSG00000180772
  
Biological name :AGTR2
  
Synonyms : AGTR2 / angiotensin II receptor type 2 / P50052
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q23
Gene start: 116170722
Gene end: 116174972
  
Corresponding Affymetrix probe sets: 207293_s_at (Human Genome U133 Plus 2.0 Array)   207294_at (Human Genome U133 Plus 2.0 Array)   222321_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360973
NCBI entrez gene - 186     See in Manteia.
OMIM - 300034
RefSeq - NM_000686
RefSeq - XM_011537533
RefSeq Peptide - NP_000677
swissprot - P50052
Ensembl - ENSG00000180772
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agtr2ENSDARG00000035552Danio rerio
 AGTR2ENSGALG00000005936Gallus gallus
 Agtr2ENSMUSG00000068122Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGTR1 / P30556 / angiotensin II receptor type 1ENSG0000014489132
RXFP3 / Q9NSD7 / relaxin/insulin like family peptide receptor 3ENSG0000018263129
BDKRB2 / P30411 / bradykinin receptor B2ENSG0000016839828
BDKRB1 / P46663 / bradykinin receptor B1ENSG0000010073926
ACKR3 / P25106 / atypical chemokine receptor 3ENSG0000014447626
APLNR / P35414 / apelin receptorENSG0000013481726
RXFP4 / Q8TDU9 / relaxin/insulin like family peptide receptor 4ENSG0000017308025
GPR15 / P49685 / G protein-coupled receptor 15ENSG0000015416525
GPR25 / O00155 / G protein-coupled receptor 25ENSG0000017012824
GPR182 / O15218 / G protein-coupled receptor 182ENSG0000016685623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000147  Angiotensin II receptor type 2
 IPR000248  Angiotensin II receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001974 blood vessel remodeling TAS
 biological_processGO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin IEA
 biological_processGO:0002018 renin-angiotensin regulation of aldosterone production IEA
 biological_processGO:0002033 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IEA
 biological_processGO:0002035 brain renin-angiotensin system IEA
 biological_processGO:0006883 cellular sodium ion homeostasis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IC
 biological_processGO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger IEA
 biological_processGO:0007263 nitric oxide mediated signal transduction TAS
 biological_processGO:0007420 brain development NAS
 biological_processGO:0008217 regulation of blood pressure TAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010459 negative regulation of heart rate IEA
 biological_processGO:0010700 negative regulation of norepinephrine secretion IEA
 biological_processGO:0021695 cerebellar cortex development IEA
 biological_processGO:0030308 negative regulation of cell growth TAS
 biological_processGO:0032304 negative regulation of icosanoid secretion IEA
 biological_processGO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035566 regulation of metanephros size IEA
 biological_processGO:0035640 exploration behavior IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0035932 aldosterone secretion IEA
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0042306 regulation of protein import into nucleus IEA
 biological_processGO:0042311 vasodilation IDA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043537 negative regulation of blood vessel endothelial cell migration NAS
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IC
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway IMP
 biological_processGO:0060993 kidney morphogenesis IEA
 biological_processGO:0061049 cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0072300 positive regulation of metanephric glomerulus development IEA
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1900116 extracellular negative regulation of signal transduction IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IC
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004945 angiotensin type II receptor activity IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0048019 receptor antagonist activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001249 Mental retardation 
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135744 AGT / P01019 / angiotensinogen  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr