Manteia - Molecule gene

ENSMUSG00000068122

Mus musculus

Features

Gene ID:	ENSMUSG00000068122

Biological name :	Agtr2

Synonyms :	Agtr2 / P35374 / Type-2 angiotensin II receptor

Possible biological names infered from orthology :	angiotensin II receptor type 2 / P50052

Species:	Mus musculus

Chr. number:	X
Strand:	1
Band:	A2
Gene start:	21484544
Gene end:	21489164

Corresponding Affymetrix probe sets:	10599001 (MoGene1.0st) 1415832_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000086592 NCBI entrez gene - 11609 See in Manteia. MGI - MGI:87966 RefSeq - NM_007429 RefSeq - XM_006527555 RefSeq Peptide - NP_031455 swissprot - P35374 Ensembl - ENSMUSG00000068122

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
agtr2	ENSDARG00000035552	Danio rerio
AGTR2	ENSGALG00000005936	Gallus gallus
AGTR2	ENSG00000180772	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*	ENSMUSG00000054988	31
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*	ENSMUSG00000049115	31
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*	ENSMUSG00000060735	28
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*	ENSMUSG00000021070	27
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*	ENSMUSG00000041347	26
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*	ENSMUSG00000044337	25
Aplnr / Q9WV08 / Apelin receptor / P35414*	ENSMUSG00000044338	25
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*	ENSMUSG00000049741	24
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*	ENSMUSG00000047293	23
Gpr182 / G protein-coupled receptor 182 / O15218*	ENSMUSG00000058396	23
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*	ENSMUSG00000052759	22

Protein motifs (from Interpro)

Interpro ID	Name
IPR000147	Angiotensin II receptor type 2
IPR000248	Angiotensin II receptor family
IPR000276	G protein-coupled receptor, rhodopsin-like
IPR017452	GPCR, rhodopsin-like, 7TM

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001822	kidney development	IEA
biological_process	GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	IMP
biological_process	GO:0002018	renin-angiotensin regulation of aldosterone production	IEA
biological_process	GO:0002033	angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure	IMP
biological_process	GO:0002035	brain renin-angiotensin system	IDA
biological_process	GO:0006883	cellular sodium ion homeostasis	IEA
biological_process	GO:0006954	inflammatory response	IGI
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007166	cell surface receptor signaling pathway	IEA
biological_process	GO:0007186	G-protein coupled receptor signaling pathway	IEA
biological_process	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA
biological_process	GO:0008284	positive regulation of cell proliferation	IEA
biological_process	GO:0010243	response to organonitrogen compound	IEA
biological_process	GO:0010459	negative regulation of heart rate	IMP
biological_process	GO:0010700	negative regulation of norepinephrine secretion	IEA
biological_process	GO:0021695	cerebellar cortex development	IEA
biological_process	GO:0032304	negative regulation of icosanoid secretion	IEA
biological_process	GO:0032516	positive regulation of phosphoprotein phosphatase activity	IEA
biological_process	GO:0035556	intracellular signal transduction	IDA
biological_process	GO:0035566	regulation of metanephros size	IMP
biological_process	GO:0035640	exploration behavior	IMP
biological_process	GO:0035815	positive regulation of renal sodium excretion	IEA
biological_process	GO:0035932	aldosterone secretion	IEA
biological_process	GO:0038166	angiotensin-activated signaling pathway	IEA
biological_process	GO:0042306	regulation of protein import into nucleus	IEA
biological_process	GO:0042311	vasodilation	IEA
biological_process	GO:0042416	dopamine biosynthetic process	IEA
biological_process	GO:0042981	regulation of apoptotic process	IEA
biological_process	GO:0045893	positive regulation of transcription, DNA-templated	IMP
biological_process	GO:0048147	negative regulation of fibroblast proliferation	IEA
biological_process	GO:0050715	positive regulation of cytokine secretion	IEA
biological_process	GO:0051000	positive regulation of nitric-oxide synthase activity	IDA
biological_process	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway	IEA
biological_process	GO:0060993	kidney morphogenesis	IEA
biological_process	GO:0061049	cell growth involved in cardiac muscle cell development	IEA
biological_process	GO:0071549	cellular response to dexamethasone stimulus	IEA
biological_process	GO:0072300	positive regulation of metanephric glomerulus development	IMP
biological_process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IEA
biological_process	GO:0097746	regulation of blood vessel diameter	IEA
biological_process	GO:0097755	positive regulation of blood vessel diameter	IEA
biological_process	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0048471	perinuclear region of cytoplasm	IEA
molecular_function	GO:0004871	obsolete signal transducer activity	IEA
molecular_function	GO:0004930	G-protein coupled receptor activity	IEA
molecular_function	GO:0004945	angiotensin type II receptor activity	ISO
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0017046	peptide hormone binding	IEA

Pathways (from Reactome)

Pathway description

Peptide ligand-binding receptors

G alpha (i) signalling events

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000183	decreased circulating LDL cholesterol level	"less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^{tm1a(EUCOMM)Wtsi}/Agtr2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Agtr2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000187	abnormal triglyceride level	"anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0000230	abnormal blood pressure	"altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb Allelic Composition: Agtr1a^tm1Afu/Agtr1a^tm1Afu,Agtr2^tm1Gsb/Y Genetic Background: mixed Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000250	abnormal vasoconstriction	"anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Abcc6^{Dyscalc1-C3H/HeNCrl}/Abcc6^{Dyscalc1-C3H/HeNCrl} Genetic Background: involves: C3H/HeNCrl * C57BL/6NCrl
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0000343	altered response to myocardial infarction	"change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0000516	abnormal urinary system morphology	"structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000519	hydronephrosis	"dilation of the pelvis and calices of one or both kidneys" [J:56641]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000520	absent kidney	"missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000521	abnormal kidney cortex	"anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0000527	abnormal kidney development	"anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000534	abnormal ureter morphology	"anomalous structure of the tube that conducts the urine from the renal pelvis to the bladder" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0000536	hydroureter	"distention of the ureter with urine, due to blockage from any cause" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:Cml, J:13044]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000818	abnormal amygdala morphology	"any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0000832	abnormal thalamus morphology	"malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Hand2^tm1.2Zllr/Hand2^tm1.2Zllr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^{tm1a(EUCOMM)Wtsi}/Agtr2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Agtr2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0001402	hypoactivity	"reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0001417	decreased exploration in new environment	"less amount of time spent investigating a new location" [J:79870]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0001431	abnormal eating behavior	"inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]	Show Allelic Composition: Stim2^tm1Beni/Stim2^tm1Beni Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001489	decreased startle reflex	"greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0001560	abnormal circulating insulin level	"anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Stim2^tm1Beni/Stim2^tm1Beni Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001622	abnormal vasculogenesis	"aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb
MP:0001629	abnormal heart rate	"greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001745	increased circulating corticosterone level	"greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001748	increased circulating adrenocorticotropin level	"elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001944	abnormal pancreas morphology	"malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001948	vesicoureteral reflux	"the retrograde flow of urine from the bladder into the ureters and kidneys" [J:77653, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002078	abnormal glucose homeostasis	"anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stim2^tm1Beni/Stim2^tm1Beni Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002118	abnormal lipid homeostasis	"anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Stim2^tm1Beni/Stim2^tm1Beni Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002135	abnormal kidney morphology	"abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002753	dilated left ventricle	"an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb
MP:0002834	decreased heart weight	"less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002842	increased blood pressure	"increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0002891	increased insulin sensitivity	"greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0002942	decreased circulating alanine transaminase level	"decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^{tm1a(EUCOMM)Wtsi}/Agtr2^{tm1a(EUCOMM)Wtsi} Genetic Background: B6JTyr;B6N-Agtr2^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0002975	vascular smooth muscle hypertrophy	"increase in size or thickness of the smooth muscle of the vascular wall" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb
MP:0003025	increased vascular smooth muscle contraction	"greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb
MP:0003043	hypoalgesia	"decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0003215	renal interstitial fibrosis	"formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0003334	pancreatic fibrosis	"invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003446	renal hypoplasia	"decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003459	increased fear-related response	"greater emotional response related to anticipation of specific pain or danger" [CFG:Center for Functional Genomics, Northwestern University]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003585	large ureter	"increased size or length of the tube that conducts the urine from the renal pelvis to the bladder" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003586	ureter dilation	"abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003600	ectopic kidney		Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003672	abnormal ureter development	"anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003916	decreased left ventricle weight	"less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0003918	decreased kidney weight	"reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003921	abnormal left ventricle morphology	"structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0003962	abnormal adrenaline level	"aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003963	abnormal corticosterone level	"anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003964	abnormal noradrenaline level	"aberrant concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004082	abnormal habenula development	"anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0004129	abnormal respiratory quotient	"anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism" [J:94416]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0004184	abnormal baroreceptor physiology	"anomaly in the function of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0004486	decreased response of heart to induced stress	"decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0004502	decreased incidence of chemically-induced tumors	"lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hand2^tm1.2Zllr/Hand2^tm1.2Zllr Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 * SJL
MP:0004875	increased mean arterial blood pressure	"increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004876	decreased mean arterial blood pressure	"decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004889	increased energy expenditure	"increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0005325	abnormal glomerulus	"anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005416	abnormal circulating protein level	"anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005502	abnormal urinary system physiology	"functional anomaly of any of the organs involved in the production or excretion of urine " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005526	decreased renal plasma flow rate	"less than the normal volume of plasma passing throught the kidney per unit time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0005531	increased renal vascular resistance	"greater than the normal force opposing blood flow in the kidney blood vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0005534	decreased body temperature	"less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0005592	abnormal vascular smooth muscle morphology	"structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb
MP:0005601	increased angiogenesis	"enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0005602	decreased angiogenesis	"reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0005659	resistance to diet-induced obesity	"less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0005667	abnormal circulating leptin level	"aberrant blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0006143	increased diastolic blood pressure	"abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6
MP:0006144	increased systolic blood pressure	"abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0006274	abnormal urine sodium level	"any change in the level of excretion of sodium in the urine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0006319	abnormal epididymal fat pad	"any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0008263	abnormal hippocampus CA1 region morphology		Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0008265	abnormal hippocampus CA2 region morphology		Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0008267	abnormal hippocampus CA3 region morphology		Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0008528	polycystic kidney	"the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008872	abnormal response to xenobiotics	"any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008873	increased sensitivity to xenobiotics	"decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009109	decreased pancreas weight	"reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009130	increased white fat cell number	"increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0009133	decreased white fat cell size	"reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0009150	pancreatic acinar cell atrophy	"wasting of the pancreatic acinar cells due to injury or disease, resulting in reduced size or number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0009643	abnormal urine homeostasis	"anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd
MP:0009763	increased sensitivity to induced morbidity/mortality	"decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Gsb/Y Genetic Background: FVB.129-Agtr2^tm1Gsb Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0009865	abnormal aorta smooth muscle morphology	"any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y,Efemp2^tm1.1Hiya/Efemp2^tm1.2Hiya,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0010009	abnormal piriform cortex morphology		Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0010182	decreased susceptibility to weight gain	"smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0010661	ascending aorta aneurysm	"a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Agtr2^tm1Tin/Y,Efemp2^tm1.1Hiya/Efemp2^tm1.2Hiya,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0010725	thin interventricular septum	"decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: B6.129P2-Agtr2^tm1Tin
MP:0010867	abnormal bone trabecula morphology	"any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010875	increased bone volume	"increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010932	increased trabecular bone connectivity density	"increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures" [ISBN:0120986523 "Principles of bone biology, Volume 1, Bilezikian, JP et al, eds"]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010996	increased aorta wall thickness	"increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Agtr2^tm1Tin/Y,Efemp2^tm1.1Hiya/Efemp2^tm1.2Hiya,Tg(Tagln-cre)1Her/0 Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr1b^tm1Cof/Agtr1b^tm1Cof,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011363	renal glomerulus atrophy	"acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011371	decreased kidney apoptosis	"decrease in the number of cells of the kidney undergoing programmed cell death" [MGI:anna]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd
MP:0011415	abnormal aldosterone level	"anomaly in the concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule" [ISBN:0-683-40008-8]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011489	ureteropelvic junction atresia	"congenital absence or closure of the connection between the ureter and the renal pelvis" [MGI:anna]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011490	ureteropelvic junction stenosis	"a constriction or narrowing of the junction between the ureter and the renal pelvis" [MGI:anna]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011492	ureterovesical junction obstruction	"a partial or total blockage of the valve-like structure found at the site of entry of the ureter into the urinary bladder" [MGI:anna]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011493	double ureter	"two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]	Show Allelic Composition: Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011501	increased glomerular capsule space	"increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]	Show Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Y Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Agtr1a^tm1Unc/Agtr1a^tm1Unc,Agtr2^tm1Tin/Agtr2^tm1Tin Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0011941	increased fluid intake	"increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6 Allelic Composition: Agtr1a^tm1Afu/Agtr1a^tm1Afu,Agtr2^tm1Gsb/Y Genetic Background: mixed
MP:0011947	abnormal fluid intake	"significant anomaly in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Atf1^tm1Gsc/Atf1⁺,Creb1^tm2Gsc/Creb1^tm2Gsc Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000031980	Agt / angiotensinogen / P01019*	/ complex / reaction

1 s.

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