ENSMUSG00000021070


Mus musculus

Features
Gene ID: ENSMUSG00000021070
  
Biological name :Bdkrb2
  
Synonyms : B2 bradykinin receptor / Bdkrb2 / P32299
  
Possible biological names infered from orthology : bradykinin receptor B2 / P30411
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: E
Gene start: 105563226
Gene end: 105595237
  
Corresponding Affymetrix probe sets: 10398117 (MoGene1.0st)   1422263_at (Mouse Genome 430 2.0 Array)   1442187_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001652
NCBI entrez gene - 12062     See in Manteia.
MGI - MGI:102845
RefSeq - NM_009747
RefSeq - XM_006515442
RefSeq Peptide - NP_033877
swissprot - P32299
Ensembl - ENSMUSG00000021070
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-63b1.1ENSDARG00000043664Danio rerio
 BDKRB2ENSGALG00000011080Gallus gallus
 BDKRB2ENSG00000168398Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*ENSMUSG0000004134729
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000004911526
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812225
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498824
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*ENSMUSG0000006073524
Aplnr / Q9WV08 / Apelin receptor / P35414*ENSMUSG0000004433823
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*ENSMUSG0000004974121
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275920
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729319
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839619
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433717


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000496  Bradykinin receptor family
 IPR001504  Bradykinin receptor B2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006939 smooth muscle contraction IEA
 biological_processGO:0006950 response to stress IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0009651 response to salt stress IGI
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IMP
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:1902219 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress IMP
 biological_processGO:1902239 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator IGI
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004947 bradykinin receptor activity ISO
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0000522 cysts in kidney cortex "abnormal membranous sacs appearing in the renal lobules, tubules and glomeruli" [J:50844]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Acetm4Keb/Acetm4Keb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001864 vasculitis "inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cadm1tm1Mrkm/Cadm1tm1Mrkm
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Tnfsf9tm1Thw/Tnfsf9tm1Thw
Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Serping1Gt1Aed/Serping1Gt1Aed
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002829 abnormal juxtaglomerular apparatus "anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Isl2tm1Gan/Isl2tm1Gan
Genetic Background: Not Specified

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Acetm4Keb/Acetm4Keb,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Isl2tm1Gan/Isl2tm1Gan
Genetic Background: Not Specified

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb1tm2Bdr/Bdkrb1tm2Bdr,Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011300 abnormal juxtaglomerular cell morphology "any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation" [MGI:anna]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011347 abnormal kidney medullary ray morphology "any structural anomaly in the center of a renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla" [ISBN:0-683-40008-8, MGI:anna]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh,Ins2Akita/Ins2+
Genetic Background: B6.Cg-Ins2Akita Bdkrb2tm1Jfh

Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

 MP:0011742 decreased urine nitrite level "lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release" [MGI:anna]
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Allelic Composition: Bdkrb2tm1Jfh/Bdkrb2tm1Jfh
Genetic Background: B6.129S7-Bdkrb2tm1Jfh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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