ENSMUSG00000044338


Mus musculus

Features
Gene ID: ENSMUSG00000044338
  
Biological name :Aplnr
  
Synonyms : Apelin receptor / Aplnr / Q9WV08
  
Possible biological names infered from orthology : P35414
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: D
Gene start: 85136225
Gene end: 85139923
  
Corresponding Affymetrix probe sets: 10473444 (MoGene1.0st)   1423037_at (Mouse Genome 430 2.0 Array)   1438651_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053638
Ensembl peptide - ENSMUSP00000139142
NCBI entrez gene - 23796     See in Manteia.
MGI - MGI:1346086
RefSeq - NM_011784
RefSeq Peptide - NP_035914
swissprot - Q9WV08
swissprot - V9GXG8
Ensembl - ENSMUSG00000044338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A0T2N3ENSDARG00000036670Danio rerio
 aplnraENSDARG00000002172Danio rerio
 APLNRENSGALG00000004841Gallus gallus
 APLNRENSG00000134817Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498828
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000004911528
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275927
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*ENSMUSG0000006073525
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*ENSMUSG0000004974125
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729325
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*ENSMUSG0000002107024
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812224
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433724
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839623
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*ENSMUSG0000004134722


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003904  APJ receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR020279  Apelin receptor, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007512 adult heart development IMP
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050878 regulation of body fluid levels IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
 biological_processGO:1904325 positive regulation of inhibitory G-protein coupled receptor phosphorylation IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001756 abnormal urination "anomaly in the production and excretion of urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002725 abnormal vein morphology "malformation of the blood vessels that carry blood towards the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0004012 increased pulmonary artery pressure "increased pulmonary pressure compared to controls" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006137 venoocclusion "blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cc2d2atm1Asw/Cc2d2atm1Asw
Genetic Background: Not Specified

Allelic Composition: Aplnrtm1Path/Aplnrtm1Path,Tg(Kdr-cre)#Brei/0
Genetic Background: involves: C57BL/6

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aplnrtm1.1Tq/Aplnrtm1.1Tq
Genetic Background: C57BL/6-Aplnrtm1.1Tq

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Aplnrtm1.1Tq/Aplnrtm1.1Tq
Genetic Background: C57BL/6-Aplnrtm1.1Tq

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0011942 decreased fluid intake "reduction in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Pin1tm1Tuc/Pin1tm1Tuc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Aplnrtm1.1Tq/Aplnrtm1.1Tq
Genetic Background: C57BL/6-Aplnrtm1.1Tq

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037010 Apln / Q9R0R4 / Apelin Apelin-36 Apelin-31 Apelin-28 Apelin-13 / apelin* / Q9ULZ1*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr