ENSMUSG00000037010


Mus musculus

Features
Gene ID: ENSMUSG00000037010
  
Biological name :Apln
  
Synonyms : Apelin Apelin-36 Apelin-31 Apelin-28 Apelin-13 / Apln / Q9R0R4
  
Possible biological names infered from orthology : apelin / Q9ULZ1
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A5
Gene start: 48025146
Gene end: 48034853
  
Corresponding Affymetrix probe sets: 10604375 (MoGene1.0st)   1451038_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000046012
NCBI entrez gene - 30878     See in Manteia.
MGI - MGI:1353624
RefSeq - NM_013912
RefSeq Peptide - NP_038940
swissprot - Q544B5
swissprot - Q9R0R4
Ensembl - ENSMUSG00000037010
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APLNENSG00000171388Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026155  Apelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0023052 signaling IBA
 biological_processGO:0031652 positive regulation of heat generation IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042756 drinking behavior ISS
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0050878 regulation of body fluid levels IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0051466 positive regulation of corticotropin-releasing hormone secretion IEA
 biological_processGO:0060183 apelin receptor signaling pathway ISO
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IEA
 biological_processGO:1904022 positive regulation of G-protein coupled receptor internalization IDA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005179 hormone activity ISO
 molecular_functionGO:0031704 apelin receptor binding ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
Show

Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0005412 vascular stenosis "narrowing or constriction of a blood vessel" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Il2rgtm1Wjl/Y,Rag1tm1Mom/Rag1tm1Mom
Genetic Background: NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Allelic Composition: Aplntm1Pngr/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
Show

Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0020329 decreased capillary density "reduction in the number of capillaries in a given cross-sectional area of a tissue" [ORCID: orcid.org/0000-0003-4606-0597, PMID:20944627]
Show

Allelic Composition: Igf1rtm1.2Mhz/Igf1rtm1.2Mhz
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000044338 Aplnr / Q9WV08 / Apelin receptor / P35414*  / complex / reaction






 

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