ENSG00000171388


Homo sapiens

Features
Gene ID: ENSG00000171388
  
Biological name :APLN
  
Synonyms : apelin / APLN / Q9ULZ1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: -1
Band: q26.1
Gene start: 129645259
Gene end: 129654937
  
Corresponding Affymetrix probe sets: 222856_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000391800
NCBI entrez gene - 8862     See in Manteia.
OMIM - 300297
RefSeq - NM_017413
RefSeq Peptide - NP_059109
swissprot - Q9ULZ1
Ensembl - ENSG00000171388
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AplnENSMUSG00000037010Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026155  Apelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0002026 regulation of the force of heart contraction IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007595 lactation TAS
 biological_processGO:0007631 feeding behavior IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010629 negative regulation of gene expression IGI
 biological_processGO:0023052 signaling IBA
 biological_processGO:0031652 positive regulation of heat generation IEA
 biological_processGO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway IGI
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0043576 regulation of respiratory gaseous exchange IEA
 biological_processGO:0045776 negative regulation of blood pressure IEA
 biological_processGO:0045823 positive regulation of heart contraction IEA
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0050878 regulation of body fluid levels IEA
 biological_processGO:0051461 positive regulation of corticotropin secretion IEA
 biological_processGO:0051466 positive regulation of corticotropin-releasing hormone secretion IEA
 biological_processGO:0060183 apelin receptor signaling pathway IEA
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 biological_processGO:1904022 positive regulation of G-protein coupled receptor internalization IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IMP
 biological_processGO:1905564 positive regulation of vascular endothelial cell proliferation IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005179 hormone activity IMP
 molecular_functionGO:0031704 apelin receptor binding IDA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134817 APLNR / P35414 / apelin receptor  / complex / reaction






 

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