ENSG00000134817


Homo sapiens

Features
Gene ID: ENSG00000134817
  
Biological name :APLNR
  
Synonyms : apelin receptor / APLNR / P35414
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q12.1
Gene start: 57233577
Gene end: 57237314
  
Corresponding Affymetrix probe sets: 213592_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000475344
Ensembl peptide - ENSP00000477818
Ensembl peptide - ENSP00000257254
NCBI entrez gene - 187     See in Manteia.
OMIM - 600052
RefSeq - NM_005161
RefSeq Peptide - NP_005152
swissprot - P35414
Ensembl - ENSG00000134817
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A0T2N3ENSDARG00000036670Danio rerio
 aplnraENSDARG00000002172Danio rerio
 APLNRENSGALG00000004841Gallus gallus
 AplnrENSMUSG00000044338Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGTR1 / P30556 / angiotensin II receptor type 1ENSG0000014489128
GPR25 / O00155 / G protein-coupled receptor 25ENSG0000017012827
GPR15 / P49685 / G protein-coupled receptor 15ENSG0000015416527
RXFP3 / Q9NSD7 / relaxin/insulin like family peptide receptor 3ENSG0000018263126
AGTR2 / P50052 / angiotensin II receptor type 2ENSG0000018077225
GPR182 / O15218 / G protein-coupled receptor 182ENSG0000016685624
RXFP4 / Q8TDU9 / relaxin/insulin like family peptide receptor 4ENSG0000017308024
ACKR3 / P25106 / atypical chemokine receptor 3ENSG0000014447623
BDKRB2 / P30411 / bradykinin receptor B2ENSG0000016839823
BDKRB1 / P46663 / bradykinin receptor B1ENSG0000010073921


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003904  APJ receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR020279  Apelin receptor, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis ISS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007507 heart development ISS
 biological_processGO:0007512 adult heart development IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IMP
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0050878 regulation of body fluid levels IEA
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0060976 coronary vasculature development ISS
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
 biological_processGO:1904325 positive regulation of inhibitory G-protein coupled receptor phosphorylation IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity TAS


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000171388 APLN / apelin / Q9ULZ1  / complex / reaction






 

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