ENSDARG00000002172


Danio rerio

Features
Gene ID: ENSDARG00000002172
  
Biological name :aplnra
  
Synonyms : apelin receptor a / aplnra / Q7SZP9
  
Possible biological names infered from orthology : apelin receptor / APLNR / P35414 / Q9WV08
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 40325690
Gene end: 40327397
  
Corresponding Affymetrix probe sets: Dr.20800.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000068614
swissprot - Q7SZP9
ZFIN ID - ZDB-GENE-060929-512
Ensembl - ENSDARG00000002172
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APLNRENSGALG00000004841Gallus gallus
 APLNRENSG00000134817Homo sapiens
 AplnrENSMUSG00000044338Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A0T2N3 / aplnrb / apelin receptor b / APLNR* / Q9WV08* / P35414* / apelin receptor*ENSDARG0000003667077
aplnr2 / apelin receptor 2ENSDARG0000000444742
agtr1b / angiotensin II receptor, type 1b / AGTR1* / P29755* / Agtr1a* / P29754* / P30556* / angiotensin II receptor type 1* / Type-1B angiotensin II receptor * / Type-1A angiotensin II receptor *ENSDARG0000004544334
agtr2 / angiotensin II receptor, type 2 / P35374* / P50052* / Type-2 angiotensin II receptor *ENSDARG0000003555232
agtr1a / angiotensin II receptor, type 1a / AGTR1* / P29755* / Agtr1b* / P29754* / P30556* / angiotensin II receptor type 1* / Type-1B angiotensin II receptor * / Type-1A angiotensin II receptor *ENSDARG0000001861632
rxfp3.2b / relaxin/insulin-like family peptide receptor 3.2bENSDARG0000006184630
gpr25 / G protein-coupled receptor 25 / O00155* / P0C5I1* / Probable G-protein coupled receptor 25 *ENSDARG0000005711229
rxfp3 / relaxin/insulin-like family peptide receptor 3 / Q8BGE9* / Q9NSD7* / Relaxin-3 receptor 1 *ENSDARG0000005741028
ackr3a / atypical chemokine receptor 3a / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*ENSDARG0000006247827
rxfp3.3a2 / relaxin/insulin-like family peptide receptor 3.3a2 / RXFP4* / Q8TDU9* / Q7TQP4* / Relaxin-3 receptor 2 * / relaxin/insulin like family peptide receptor 4*ENSDARG0000006211127
rxfp3.3b / relaxin/insulin-like family peptide receptor 3.3b / RXFP4* / Q8TDU9* / Q7TQP4* / Relaxin-3 receptor 2 * / relaxin/insulin like family peptide receptor 4*ENSDARG0000005934827
ackr3b / atypical chemokine receptor 3b / ACKR3* / P25106* / P56485* / atypical chemokine receptor 3*ENSDARG0000005817927
si:dkey-63b1.1 / BDKRB2* / P30411* / P32299* / bradykinin receptor B2* / B2 bradykinin receptor *ENSDARG0000004366427
rxfp3.3a1 / relaxin/insulin-like family peptide receptor 3.3a1 / RXFP4* / Q8TDU9* / Q7TQP4* / Relaxin-3 receptor 2 * / relaxin/insulin like family peptide receptor 4*ENSDARG0000006902826
rxfp3.3a3 / relaxin/insulin-like family peptide receptor 3.3a3 / RXFP4* / Q8TDU9* / Q7TQP4* / Relaxin-3 receptor 2 * / relaxin/insulin like family peptide receptor 4*ENSDARG0000006924626
bdkrb1 / bradykinin receptor B1 / P46663* / Q61125* / B1 bradykinin receptor *ENSDARG0000002074424
gpr182 / G protein-coupled receptor 182 / O15218*ENSDARG0000003661620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000248  Angiotensin II receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis ISS
 biological_processGO:0001702 gastrulation with mouth forming second ISS
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0035479 angioblast cell migration from lateral mesoderm to midline IMP
 biological_processGO:0035987 endodermal cell differentiation IGI
 biological_processGO:0042074 cell migration involved in gastrulation IMP
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling ISS
 biological_processGO:0045766 positive regulation of angiogenesis ISS
 biological_processGO:0048738 cardiac muscle tissue development ISS
 biological_processGO:0051281 positive regulation of release of sequestered calcium ion into cytosol ISS
 biological_processGO:0055113 epiboly involved in gastrulation with mouth forming second IMP
 biological_processGO:0060976 coronary vasculature development ISS
 biological_processGO:1900107 regulation of nodal signaling pathway IGI
 biological_processGO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis ISS
 biological_processGO:1904325 positive regulation of inhibitory G-protein coupled receptor phosphorylation ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000028 heart primordium heart primordium hypoplastic , abnormal
heart primordium decreased distribution , abnormal
heart primordium decreased amount , abnormal
heart primordium absent , abnormal
Show

 ZFA:0000038 margin margin decreased amount , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye fused with eye , abnormal
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 ZFA:0000114 heart heart dysplastic , abnormal
heart hypoplastic , abnormal
heart aplastic , abnormal
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 ZFA:0000123 liver liver decreased size , abnormal
liver aplastic/hypoplastic , abnormal
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 ZFA:0001378 axial hypoblast axial hypoblast decreased amount , abnormal
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 ZFA:0001390 pancreatic bud pancreatic bud position , abnormal
pancreatic bud decreased size , abnormal
pancreatic bud aplastic/hypoplastic , abnormal
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 ZFA:0005110 thoracic duct thoracic duct has fewer parts of type endothelial cell , abnormal
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 ZFA:0009139 endodermal cell endodermal cell decreased distribution , abnormal
endodermal cell decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte increased accumulation blood island , abnormal
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 ZFA:0009316 cardiac muscle cell cardiac muscle cell decreased distribution , abnormal
cardiac muscle cell decreased amount , abnormal
cardiac muscle cell absent , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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