ENSG00000144476


Homo sapiens

Features
Gene ID: ENSG00000144476
  
Biological name :ACKR3
  
Synonyms : ACKR3 / atypical chemokine receptor 3 / P25106
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 236567787
Gene end: 236582358
  
Corresponding Affymetrix probe sets: 1559114_a_at (Human Genome U133 Plus 2.0 Array)   212977_at (Human Genome U133 Plus 2.0 Array)   232746_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405945
Ensembl peptide - ENSP00000272928
NCBI entrez gene - 57007     See in Manteia.
OMIM - 610376
RefSeq - XM_017004516
RefSeq - NM_020311
RefSeq - XM_005246097
RefSeq - XM_005246098
RefSeq Peptide - NP_064707
swissprot - A0A140T9K6
swissprot - P25106
Ensembl - ENSG00000144476
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ackr3aENSDARG00000062478Danio rerio
 ackr3bENSDARG00000058179Danio rerio
 ACKR3ENSGALG00000021031Gallus gallus
 Ackr3ENSMUSG00000044337Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
GPR182 / O15218 / G protein-coupled receptor 182ENSG0000016685630
AGTR1 / P30556 / angiotensin II receptor type 1ENSG0000014489127
AGTR2 / P50052 / angiotensin II receptor type 2ENSG0000018077226
RXFP3 / Q9NSD7 / relaxin/insulin like family peptide receptor 3ENSG0000018263126
APLNR / P35414 / apelin receptorENSG0000013481725
GPR15 / P49685 / G protein-coupled receptor 15ENSG0000015416524
BDKRB1 / P46663 / bradykinin receptor B1ENSG0000010073923
RXFP4 / Q8TDU9 / relaxin/insulin like family peptide receptor 4ENSG0000017308022
BDKRB2 / P30411 / bradykinin receptor B2ENSG0000016839821
GPR25 / O00155 / G protein-coupled receptor 25ENSG0000017012821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001416  Atypical chemokine receptor 3
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031623 receptor internalization IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
 biological_processGO:1905322 positive regulation of mesenchymal stem cell migration IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005044 scavenger receptor activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IMP
 molecular_functionGO:0019956 chemokine binding IEA
 molecular_functionGO:0019958 C-X-C chemokine binding IMP


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107562 CXCL12 / P48061 / C-X-C motif chemokine ligand 12  / reaction / complex






 

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