ENSMUSG00000049741


Mus musculus

Features
Gene ID: ENSMUSG00000049741
  
Biological name :Rxfp4
  
Synonyms : Q7TQP4 / Relaxin-3 receptor 2 / Rxfp4
  
Possible biological names infered from orthology : Q8TDU9 / relaxin/insulin like family peptide receptor 4
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 88651898
Gene end: 88653142
  
Corresponding Affymetrix probe sets: 10499427 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000058732
NCBI entrez gene - 242093     See in Manteia.
MGI - MGI:2182926
RefSeq - NM_181817
RefSeq Peptide - NP_861538
swissprot - Q5Y985
swissprot - Q7TQP4
Ensembl - ENSMUSG00000049741
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rxfp3.3a1ENSDARG00000069028Danio rerio
 rxfp3.3a2ENSDARG00000062111Danio rerio
 rxfp3.3a3ENSDARG00000069246Danio rerio
 rxfp3.3bENSDARG00000059348Danio rerio
 RXFP4ENSG00000173080Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*ENSMUSG0000006073533
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275922
Aplnr / Q9WV08 / Apelin receptor / P35414*ENSMUSG0000004433822
Agtr1a / P29754 / Type-1A angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000004911521
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812221
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*ENSMUSG0000004134721
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*ENSMUSG0000002107020
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498820
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433718
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729317
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000248  Angiotensin II receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:2000253 positive regulation of feeding behavior IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004966 galanin receptor activity IBA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0001432 abnormal food preference "the desire to eat more or less food than average, or to eat unusual foods" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0009293 decreased inguinal fat pad weight 
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0011957 decreased compensatory feeding amount "decreased amount of food consumed after a period of fasting" [MGI:csmith]
Show

Allelic Composition: Rb1tm2Brn/Rb1tm2Brn,Trp53tm1Brn/Trp53tm1Brn,Tg(Ren-cre)#Kwg/0
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
Show

Allelic Composition: Rock1tm1b(NCOM)Mfgc/Rock1tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Rock1tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045232 Rln3 / Q8CHK2 / Relaxin-3 Relaxin-3 B chain Relaxin-3 A chain / Q8WXF3* / relaxin 3*  / complex / reaction
 ENSMUSG00000066090 Insl5 / Q9WUG6 / Insulin-like peptide INSL5 Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain / Q9Y5Q6* / insulin like 5*  / reaction / complex






 

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