ENSMUSG00000066090


Mus musculus

Features
Gene ID: ENSMUSG00000066090
  
Biological name :Insl5
  
Synonyms : Insl5 / Insulin-like peptide INSL5 Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain / Q9WUG6
  
Possible biological names infered from orthology : insulin like 5 / Q9Y5Q6
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C6
Gene start: 103017872
Gene end: 103026842
  
Corresponding Affymetrix probe sets: 10514708 (MoGene1.0st)   1449493_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000081416
Ensembl peptide - ENSMUSP00000102482
NCBI entrez gene - 23919     See in Manteia.
MGI - MGI:1346085
RefSeq - NM_001290648
RefSeq - NM_011831
RefSeq Peptide - NP_001277577
RefSeq Peptide - NP_035961
swissprot - Q9WUG6
swissprot - A2AIY3
Ensembl - ENSMUSG00000066090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 INSL5ENSG00000172410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR016179  Insulin-like
 IPR022353  Insulin, conserved site
 IPR036438  Insulin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:2000253 positive regulation of feeding behavior IGI
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IBA
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Relaxin receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

Allelic Composition: Insl5tm1Dgen/Insl5tm1Dgen
Genetic Background: B6.129-Insl5tm1Dgen/J

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Slc2a8tm1Khm/Slc2a8+
Genetic Background: involves: 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000049741 Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*  / reaction / complex
 ENSMUSG00000066090 Insl5 / Q9WUG6 / Insulin-like peptide INSL5 Insulin-like peptide INSL5 B chain Insulin-like peptide INSL5 A chain / Q9Y5Q6* / insulin like 5*  / complex






 

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