ENSMUSG00000049115


Mus musculus

Features
Gene ID: ENSMUSG00000049115
  
Biological name :Agtr1a
  
Synonyms : Agtr1a / P29754 / Type-1A angiotensin II receptor
  
Possible biological names infered from orthology : AGTR1 / angiotensin II receptor type 1 / P30556
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.2
Gene start: 30336441
Gene end: 30382867
  
Corresponding Affymetrix probe sets: 10404376 (MoGene1.0st)   1436739_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070958
Ensembl peptide - ENSMUSP00000152873
Ensembl peptide - ENSMUSP00000152634
Ensembl peptide - ENSMUSP00000152265
Ensembl peptide - ENSMUSP00000152133
NCBI entrez gene - 11607     See in Manteia.
MGI - MGI:87964
RefSeq - XM_011244264
RefSeq - NM_177322
RefSeq - XM_006516534
RefSeq Peptide - NP_796296
swissprot - A0A1Y7VL16
swissprot - A0A1Y7VMR7
swissprot - P29754
swissprot - A0A1Y7VJY2
swissprot - A0A1Y7VIT7
Ensembl - ENSMUSG00000049115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agtr1aENSDARG00000018616Danio rerio
 agtr1bENSDARG00000045443Danio rerio
 AGTR1ENSGALG00000038512Gallus gallus
 AGTR1ENSG00000144891Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agtr1b / P29755 / Type-1B angiotensin II receptor / AGTR1* / P30556* / angiotensin II receptor type 1*ENSMUSG0000005498894
Agtr2 / P35374 / Type-2 angiotensin II receptor / P50052* / angiotensin II receptor type 2*ENSMUSG0000006812231
Rxfp3 / Q8BGE9 / Relaxin-3 receptor 1 / Q9NSD7* / relaxin/insulin like family peptide receptor 3*ENSMUSG0000006073530
Aplnr / Q9WV08 / Apelin receptor / P35414*ENSMUSG0000004433829
Bdkrb2 / P32299 / B2 bradykinin receptor / P30411* / bradykinin receptor B2*ENSMUSG0000002107028
Bdkrb1 / Q61125 / B1 bradykinin receptor / P46663* / bradykinin receptor B1*ENSMUSG0000004134727
Gpr25 / P0C5I1 / Probable G-protein coupled receptor 25 / O00155* / G protein-coupled receptor 25*ENSMUSG0000005275926
Gpr15 / Q0VDU3 / G-protein coupled receptor 15 / P49685*ENSMUSG0000004729326
Ackr3 / P56485 / atypical chemokine receptor 3 / P25106*ENSMUSG0000004433725
Rxfp4 / Q7TQP4 / Relaxin-3 receptor 2 / Q8TDU9* / relaxin/insulin like family peptide receptor 4*ENSMUSG0000004974124
Gpr182 / G protein-coupled receptor 182 / O15218*ENSMUSG0000005839624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000190  Angiotensin II receptor type 1
 IPR000248  Angiotensin II receptor family
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0001822 kidney development ISO
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin IGI
 biological_processGO:0002001 renin secretion into blood stream IMP
 biological_processGO:0002018 renin-angiotensin regulation of aldosterone production IEA
 biological_processGO:0002019 regulation of renal output by angiotensin IMP
 biological_processGO:0002035 brain renin-angiotensin system IMP
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0006954 inflammatory response IGI
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007266 Rho protein signal transduction ISO
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009651 response to salt stress IEA
 biological_processGO:0010873 positive regulation of cholesterol esterification ISO
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0032270 positive regulation of cellular protein metabolic process ISO
 biological_processGO:0032430 positive regulation of phospholipase A2 activity ISO
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0034391 regulation of smooth muscle cell apoptotic process IGI
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IMP
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042416 dopamine biosynthetic process IEA
 biological_processGO:0042756 drinking behavior IEA
 biological_processGO:0042976 activation of Janus kinase activity IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045777 positive regulation of blood pressure IEA
 biological_processGO:0050715 positive regulation of cytokine secretion IMP
 biological_processGO:0051412 response to corticosterone IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
 biological_processGO:0060326 cell chemotaxis ISO
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0086097 phospholipase C-activating angiotensin-activated signaling pathway ISO
 biological_processGO:0090190 positive regulation of branching involved in ureteric bud morphogenesis IEA
 biological_processGO:1990776 response to angiotensin IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0012506 vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031968 organelle outer membrane IEA
 cellular_componentGO:0031983 vesicle lumen IEA
 cellular_componentGO:0055037 recycling endosome IEA
 molecular_functionGO:0001596 angiotensin type I receptor activity IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004945 angiotensin type II receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017046 peptide hormone binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0031711 bradykinin receptor binding ISO
 molecular_functionGO:0031748 D1 dopamine receptor binding IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000230 abnormal blood pressure "altered tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
Genetic Background: mixed

Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000530 abnormal kidney vasculature "malformation or malfunctioning of the blood vessel network of the organ of excretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000818 abnormal amygdala morphology "any malformation or absence of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: B6.129P2-Agtr2tm1Tin

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr2tm1Tin/Y
Genetic Background: B6.129P2-Agtr2tm1Tin

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Agtr1atm1Afu/Agtr1a+
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crkltm1Hkp/Crkltm1Hkp
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss

 MP:0002593 high mean erythrocyte count "greater than average numbers of red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002829 abnormal juxtaglomerular apparatus "anomalous structure or development of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pik3cgtm1Wym/Pik3cgtm1Wym
Genetic Background: either: 129/Sv-Pik3cgtm1Wym or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003211 abnormal aorta elastic fiber morphology "malformation of a slender connective tissue fiber in aortic tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0003353 decreased circulating renin level "reduced blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003918 decreased kidney weight "reduced heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003985 renal fibrosis "formation of fibrous tissue in the kidney as a result of repair or a reactive process" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm4Mae/Apoetm4Mae
Genetic Background: 129S6/SvEvTac-Apoetm4Mae

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005582 increased renin activity "greater than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu
Genetic Background: involves: C57BL/6 * CBA * ICR

 MP:0005583 decreased renin activity "less than the normal ability of this enzyme to cleave angiotensinogen and create angiotensin I" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Hprttm1(Ggt1-Agtr1)Cof/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Agtr1atm1Afu/Agtr1a+
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agtr1atm1Unc/Agtr1a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0006376 decreased circulating angiotensinogen level "less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009867 abnormal ascending aorta morphology "any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1.1Cof/Agtr1atm1.1Cof,Hprttm1(Pck1-cre)Vhh/Hprt+
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010661 ascending aorta aneurysm "a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.129-Ldlrtm1Her Agtr1atm1Unc

 MP:0010996 increased aorta wall thickness "increased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Efemp2tm1.1Hiya/Efemp2tm1.2Hiya,Tg(Tagln-cre)1Her/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010997 decreased aorta wall thickness "decreased depth of the part of the aorta that encloses the luminal space" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Cd247tm2.1Lov/Cd247tm2.1Lov,Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011301 juxtaglomerular cell hyperplasia "increased number of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa" [MGI:anna]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011305 dilated kidney calyx "an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:anna]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011306 absent kidney pelvis "absence of the funnel shaped proximal portion of the ureter, normally formed by convergence of the major calices" [MGI:anna]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011316 abnormal kidney interlobular artery morphology "any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli" [ISBN:0-683-40008-8]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm2Tma/Agtr1atm2Tma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011363 renal glomerulus atrophy "acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011425 abnormal kidney interstitium morphology "any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure" [MGI:anna]
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Allelic Composition: Gnai2tm1Lbi/Gnai2tm1Lbi
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Agtr1atm1Ecl/Agtr1atm1Ecl
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011501 increased glomerular capsule space "increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries" [MGI:csmith]
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Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr1btm1Cof/Agtr1btm1Cof
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Agtr1atm1Unc/Agtr1atm1Unc,Agtr2tm1Tin/Agtr2tm1Tin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011565 kidney papillary hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx" [MGI:anna]
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Allelic Composition: Agtr1atm1Tma/Agtr1atm1Tma,Agtr1btm1Ii/Agtr1btm1Ii
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu
Genetic Background: involves: C57BL/6 * CBA * ICR

Allelic Composition: Agtr1atm1Afu/Agtr1atm1Afu,Agtr2tm1Gsb/Y
Genetic Background: mixed

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031980 Agt / angiotensinogen / P01019*  / reaction / complex






 

1 s.

 
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