ENSG00000066056


Homo sapiens

Features
Gene ID: ENSG00000066056
  
Biological name :TIE1
  
Synonyms : P35590 / TIE1 / tyrosine kinase with immunoglobulin like and EGF like domains 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 43300993
Gene end: 43323108
  
Corresponding Affymetrix probe sets: 1560657_at (Human Genome U133 Plus 2.0 Array)   204468_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361554
Ensembl peptide - ENSP00000440063
NCBI entrez gene - 7075     See in Manteia.
OMIM - 600222
RefSeq - XM_006710869
RefSeq - NM_001253357
RefSeq - NM_005424
RefSeq - XM_005271163
RefSeq Peptide - NP_001240286
RefSeq Peptide - NP_005415
swissprot - P35590
Ensembl - ENSG00000066056
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tie1ENSDARG00000004105Danio rerio
 TIE1ENSGALG00000009957Gallus gallus
 Tie1ENSMUSG00000033191Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TEK / Q02763 / TEK receptor tyrosine kinaseENSG0000012015646
MST1R / Q04912 / macrophage stimulating 1 receptorENSG0000016407818
AXL / P30530 / AXL receptor tyrosine kinaseENSG0000016760117
TYRO3 / Q06418 / TYRO3 protein tyrosine kinaseENSG0000009244517
MERTK / Q12866 / MER proto-oncogene, tyrosine kinaseENSG0000015320817
MET / P08581 / MET proto-oncogene, receptor tyrosine kinaseENSG0000010597616
RYK / receptor-like tyrosine kinaseENSG0000016378512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000742  EGF-like domain
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007498 mesoderm development TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0045026 plasma membrane fusion IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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