ENSG00000160007


Homo sapiens

Features
Gene ID: ENSG00000160007
  
Biological name :ARHGAP35
  
Synonyms : ARHGAP35 / Q9NRY4 / Rho GTPase activating protein 35
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 46918676
Gene end: 47005077
  
Corresponding Affymetrix probe sets: 202044_at (Human Genome U133 Plus 2.0 Array)   202045_s_at (Human Genome U133 Plus 2.0 Array)   202046_s_at (Human Genome U133 Plus 2.0 Array)   229394_s_at (Human Genome U133 Plus 2.0 Array)   229397_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385720
Ensembl peptide - ENSP00000483730
NCBI entrez gene - 2909     See in Manteia.
OMIM - 605277
RefSeq - XM_017026714
RefSeq - NM_004491
RefSeq - XM_011526873
RefSeq Peptide - NP_004482
swissprot - Q9NRY4
Ensembl - ENSG00000160007
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap35aENSDARG00000062577Danio rerio
 arhgap35bENSDARG00000060297Danio rerio
 Q91YM2ENSMUSG00000058230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13017 / ARHGAP5 / Rho GTPase activating protein 5ENSG0000010085251
ARAP2 / Q8WZ64 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2ENSG0000004736513
ARAP1 / Q96P48 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1ENSG0000018663512
ARAP3 / Q8WWN8 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3ENSG0000012031812


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001806  Small GTPase superfamily
 IPR002713  FF domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032835  Rho GTPase-activating protein, FF domain
 IPR036517  FF domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0006351 transcription, DNA-templated TAS
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007411 axon guidance ISS
 biological_processGO:0007413 axonal fasciculation ISS
 biological_processGO:0008064 regulation of actin polymerization or depolymerization ISS
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0016477 cell migration ISS
 biological_processGO:0021955 central nervous system neuron axonogenesis ISS
 biological_processGO:0030879 mammary gland development ISS
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030950 establishment or maintenance of actin cytoskeleton polarity ISS
 biological_processGO:0031668 cellular response to extracellular stimulus ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISS
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043116 negative regulation of vascular permeability IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0044319 wound healing, spreading of cells ISS
 biological_processGO:0045724 positive regulation of cilium assembly ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0050770 regulation of axonogenesis ISS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0097485 neuron projection guidance ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036064 ciliary basal body ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003714 transcription corepressor activity TAS
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005543 phospholipid binding IDA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Sema4D mediated inhibition of cell attachment and migration
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000164050 O43157 / PLXNB1 / plexin B1  / complex / reaction
 ENSG00000145715 RASA1 / P20936 / RAS p21 protein activator 1  / reaction / complex
 ENSG00000172602 RND1 / Q92730 / Rho family GTPase 1  / reaction / complex
 ENSG00000105976 MET / P08581 / MET proto-oncogene, receptor tyrosine kinase  / complex / reaction
 ENSG00000187764 Q92854 / SEMA4D / semaphorin 4D  / reaction / complex
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction






 

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