ENSG00000186635


Homo sapiens

Features
Gene ID: ENSG00000186635
  
Biological name :ARAP1
  
Synonyms : ARAP1 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 / Q96P48
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q13.4
Gene start: 72685069
Gene end: 72793599
  
Corresponding Affymetrix probe sets: 212516_at (Human Genome U133 Plus 2.0 Array)   242039_at (Human Genome U133 Plus 2.0 Array)   34206_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000403127
Ensembl peptide - ENSP00000442746
Ensembl peptide - ENSP00000441741
Ensembl peptide - ENSP00000411452
Ensembl peptide - ENSP00000335506
Ensembl peptide - ENSP00000352332
Ensembl peptide - ENSP00000377230
Ensembl peptide - ENSP00000377233
Ensembl peptide - ENSP00000390461
Ensembl peptide - ENSP00000392264
Ensembl peptide - ENSP00000399118
NCBI entrez gene - 116985     See in Manteia.
OMIM - 606646
RefSeq - NM_001135190
RefSeq - NM_015242
RefSeq - NM_001040118
RefSeq Peptide - NP_001035207
RefSeq Peptide - NP_001128662
RefSeq Peptide - NP_056057
swissprot - Q96P48
swissprot - A0A0A0MSJ2
swissprot - F5GWN4
swissprot - F5GWQ2
swissprot - F8WBT0
swissprot - H0YGD1
swissprot - E7EU13
Ensembl - ENSG00000186635
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-135f11.1ENSDARG00000062221Danio rerio
 Arap1ENSMUSG00000032812Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARAP2 / Q8WZ64 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2ENSG0000004736536
ARAP3 / Q8WWN8 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3ENSG0000012031834
Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35ENSG0000016000713
Q13017 / ARHGAP5 / Rho GTPase activating protein 5ENSG0000010085211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0030037 actin filament reorganization involved in cell cycle TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051270 regulation of cellular component movement IMP
 biological_processGO:0051491 positive regulation of filopodium assembly IMP
 biological_processGO:0051497 negative regulation of stress fiber assembly IMP
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101213 PTK6 / Q13882 / protein tyrosine kinase 6  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr