ENSMUSG00000032812


Mus musculus

Features
Gene ID: ENSMUSG00000032812
  
Biological name :Arap1
  
Synonyms : Arap1 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q4LDD4
  
Possible biological names infered from orthology : ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 / Q96P48
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E2
Gene start: 101348067
Gene end: 101412586
  
Corresponding Affymetrix probe sets: 10555470 (MoGene1.0st)   1428064_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102624
Ensembl peptide - ENSMUSP00000147974
Ensembl peptide - ENSMUSP00000123542
Ensembl peptide - ENSMUSP00000121431
Ensembl peptide - ENSMUSP00000121257
Ensembl peptide - ENSMUSP00000120168
Ensembl peptide - ENSMUSP00000118657
Ensembl peptide - ENSMUSP00000115850
Ensembl peptide - ENSMUSP00000115107
Ensembl peptide - ENSMUSP00000114197
Ensembl peptide - ENSMUSP00000081957
Ensembl peptide - ENSMUSP00000081958
Ensembl peptide - ENSMUSP00000095844
NCBI entrez gene - 69710     See in Manteia.
MGI - MGI:1916960
RefSeq - XM_006508195
RefSeq - XM_006508187
RefSeq - XM_006508186
RefSeq - XM_006508193
RefSeq - XM_006508192
RefSeq - XM_006508191
RefSeq - XM_006508190
RefSeq - XM_006508189
RefSeq - NM_001040111
RefSeq - NM_001040112
RefSeq - NM_027180
RefSeq - NM_198096
RefSeq - XM_011241897
RefSeq - XM_006508196
RefSeq - XM_006508188
RefSeq Peptide - NP_001035201
RefSeq Peptide - NP_001035200
RefSeq Peptide - NP_081456
RefSeq Peptide - NP_932764
swissprot - Q4LDD4
swissprot - E9PUB0
swissprot - A0A1B0GSK4
swissprot - D3YVS8
swissprot - D3YWW7
swissprot - D3YY40
swissprot - D3YYF5
swissprot - D3YZJ7
swissprot - D3Z2S2
swissprot - D3Z2X3
Ensembl - ENSMUSG00000032812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-135f11.1ENSDARG00000062221Danio rerio
 ARAP1ENSG00000186635Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arap2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 / Q8WZ64*ENSMUSG0000003799936
Arap3 / Q8R5G7 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 / Q8WWN8* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3*ENSMUSG0000002445133
Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*ENSMUSG0000005823013
Arhgap5 / Rho GTPase activating protein 5 / Q13017*ENSMUSG0000003513312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway ISS
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0051270 regulation of cellular component movement ISO
 biological_processGO:0051491 positive regulation of filopodium assembly ISO
 biological_processGO:0051497 negative regulation of stress fiber assembly ISO
 biological_processGO:0060395 SMAD protein signal transduction ISS
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005802 trans-Golgi network IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISS
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0031702 type 1 angiotensin receptor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070412 R-SMAD binding ISS


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Acp2tm1a(EUCOMM)Wtsi/Acp2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Acp2tm1a(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038751 Ptk6 / Q64434 / PTK6 protein tyrosine kinase 6 / Q13882* / protein tyrosine kinase 6*  / reaction / complex






 

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