ENSMUSG00000035133


Mus musculus

Features
Gene ID: ENSMUSG00000035133
  
Biological name :Arhgap5
  
Synonyms : Arhgap5 / Rho GTPase activating protein 5
  
Possible biological names infered from orthology : Q13017
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C1
Gene start: 52503972
Gene end: 52571975
  
Corresponding Affymetrix probe sets: 10395692 (MoGene1.0st)   1423194_at (Mouse Genome 430 2.0 Array)   1437987_at (Mouse Genome 430 2.0 Array)   1450896_at (Mouse Genome 430 2.0 Array)   1450897_at (Mouse Genome 430 2.0 Array)   1457410_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151267
Ensembl peptide - ENSMUSP00000151809
Ensembl peptide - ENSMUSP00000106353
NCBI entrez gene - 11855     See in Manteia.
MGI - MGI:1332637
RefSeq - XM_011243990
RefSeq - XM_006515438
RefSeq - XM_006515439
RefSeq - XM_011243989
RefSeq - NM_009706
RefSeq Peptide - NP_033836
swissprot - A0A1W2P6H9
swissprot - E9PYT0
Ensembl - ENSMUSG00000035133
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgap5ENSDARG00000061294Danio rerio
 ARHGAP5ENSGALG00000009992Gallus gallus
 Q13017ENSG00000100852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*ENSMUSG0000005823051
Arap3 / Q8R5G7 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 / Q8WWN8* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3*ENSMUSG0000002445112
Arap2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 / Q8WZ64*ENSMUSG0000003799912
Arap1 / Q4LDD4 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1*ENSMUSG0000003281211


Protein motifs (from Interpro)
Interpro ID Name
 IPR000198  Rho GTPase-activating protein domain
 IPR001806  Small GTPase superfamily
 IPR002713  FF domain
 IPR008936  Rho GTPase activation protein
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032835  Rho GTPase-activating protein, FF domain
 IPR036517  FF domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0030879 mammary gland development IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0042169 SH2 domain binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000781 reduced size of corpus callosum "smaller commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008226 decreased anterior commissure size "reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr