ENSMUSG00000024451


Mus musculus

Features
Gene ID: ENSMUSG00000024451
  
Biological name :Arap3
  
Synonyms : Arap3 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 / Q8R5G7
  
Possible biological names infered from orthology : ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 / Q8WWN8
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 37972624
Gene end: 37997574
  
Corresponding Affymetrix probe sets: 10458498 (MoGene1.0st)   1419833_s_at (Mouse Genome 430 2.0 Array)   1447407_at (Mouse Genome 430 2.0 Array)   1451282_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000035662
NCBI entrez gene - 106952     See in Manteia.
MGI - MGI:2147274
RefSeq - XM_011246799
RefSeq - NM_001205336
RefSeq - NM_139206
RefSeq - XM_006525490
RefSeq - XM_006525491
RefSeq - XM_006525492
RefSeq - XM_006525486
RefSeq - XM_006525487
RefSeq - XM_006525488
RefSeq - XM_006525489
RefSeq Peptide - NP_631945
RefSeq Peptide - NP_001192265
swissprot - Q8R5G7
Ensembl - ENSMUSG00000024451
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arap3ENSDARG00000076801Danio rerio
 ARAP3ENSGALG00000002562Gallus gallus
 ARAP3ENSG00000120318Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arap2 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 / Q8WZ64*ENSMUSG0000003799933
Arap1 / Q4LDD4 / Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 / Q96P48* / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1*ENSMUSG0000003281231
Q91YM2 / Arhgap35 / Rho GTPase activating protein 35 / Q9NRY4*ENSMUSG0000005823012
Arhgap5 / Rho GTPase activating protein 5 / Q13017*ENSMUSG0000003513312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IDA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction IDA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005096 GTPase activator activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.2Sve/Arap3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

 MP:0004950 abnormal brain vasculature "any structural anomaly of the blood vessel network of the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.2Sve/Arap3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0009577 abnormal developmental vascular remodeling "any anomaly in the process by which existing vessels are reorganized during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

Allelic Composition: Arap3tm2.1Sve/Arap3tm2.1Sve
Genetic Background: involves: 129P2/OlaHsd

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Tg(ACTA1-SSPN)3.0Rcros/0
Genetic Background: involves: C57BL/10ScSn

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * SJL

Allelic Composition: Arap3tm1.1Sve/Arap3tm1.2Sve,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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