ENSG00000120318


Homo sapiens

Features
Gene ID: ENSG00000120318
  
Biological name :ARAP3
  
Synonyms : ARAP3 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 / Q8WWN8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q31.3
Gene start: 141653401
Gene end: 141682221
  
Corresponding Affymetrix probe sets: 218950_at (Human Genome U133 Plus 2.0 Array)   235806_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421148
Ensembl peptide - ENSP00000421826
Ensembl peptide - ENSP00000486980
Ensembl peptide - ENSP00000239440
Ensembl peptide - ENSP00000421468
NCBI entrez gene - 64411     See in Manteia.
OMIM - 606647
RefSeq - XM_011537677
RefSeq - NM_022481
RefSeq - XM_005268497
RefSeq - XM_005268498
RefSeq - XM_005268499
RefSeq - XM_006714792
RefSeq Peptide - NP_071926
swissprot - Q05CH1
swissprot - Q8WWN8
swissprot - G5E9Y3
Ensembl - ENSG00000120318
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arap3ENSDARG00000076801Danio rerio
 ARAP3ENSGALG00000002562Gallus gallus
 Arap3ENSMUSG00000024451Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ARAP2 / Q8WZ64 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2ENSG0000004736534
ARAP1 / Q96P48 / ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1ENSG0000018663532
Q13017 / ARHGAP5 / Rho GTPase activating protein 5ENSG0000010085212
Q9NRY4 / ARHGAP35 / Rho GTPase activating protein 35ENSG0000016000712


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR000198  Rho GTPase-activating protein domain
 IPR001164  Arf GTPase activating protein
 IPR001660  Sterile alpha motif domain
 IPR001849  Pleckstrin homology domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR029071  Ubiquitin-like domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008360 regulation of cell shape ISS
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0030336 negative regulation of cell migration ISS
 biological_processGO:0035021 negative regulation of Rac protein signal transduction IEA
 biological_processGO:0035024 negative regulation of Rho protein signal transduction ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 cellular_componentGO:0001726 ruffle ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium ISS
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Rho GTPase cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr